Journal of Oral Medicine and Pain

Korean Academy of Orofacial Pain and Oral Medicine (대한안면통증구강내과학회)
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Application of Stress Hormones in Saliva in Research of Orofacial Pain Related with Stress

스트레스와 관련된 구강안면통증의 연구에 있어서 타액내의 스트레스호르몬의 활용

  • Ryu, Ji-Won (Department of Oral Medicine, College of Dentistry, Chosun University) ;
  • Yoon, Chang-Lyuk (Department of Oral Medicine, College of Dentistry, Chosun University) ;
  • Ahn, Jong-Mo (Department of Oral Medicine, College of Dentistry, Chosun University)
  • 유지원 (조선대학교 치과대학 구강내과학교실) ;
  • 윤창륙 (조선대학교 치과대학 구강내과학교실) ;
  • 안종모 (조선대학교 치과대학 구강내과학교실)
  • Published : 2007.06.30
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Abstract

Many diseases occur by stress or effect of stress. The basis for using hormones in research of stress is the observation that most systems in the body show changes during stress and that hormonal markers in these changes are related with stress. Conceptually, the central role of sympathetic nervous system(SNS) and hypothalamus-pituitary-adrenal(HPA) axis activity in stress provides copious justification for measuring hormonal changes. Catecholamines like epinephrine and norepinephrine, cortisol, testosterone and growth hormone and so on show sensitive reaction to stress. The major advantage of salivary sample to stress research is that its sampling technique can be performed in non-stressful conditions and without physical restraint and ethical problems. Because hormone levels in saliva is a good reflection of hormone levels in plasma, application of stress hormones in saliva is very useful for research of orofacial pain related with stress.

많은 질병들과 기존에 존재하는 신체적인 질병들은 스트레스로 인해 발병되거나 크고 작은 스트레스의 영향으로 악화된다. 스트레스의 연구에 호르몬을 사용하는 기본은 신체의 대부분 시스템이 스트레스를 받는 동안 변화를 보인다는 것과 이러한 변화에 호르몬이 스트레스와 확실하게 연관되어 있다는 것을 관찰하는 것이다. 개념적으로 스트레스에 있어서 교감신경계와 시상하부-뇌하수체-부신축의 활성화가 중심적인 역할을 한다는 것이 호르몬의 변화를 측정해야 할 충분한 근거를 제공한다. 에피네프린과 노르에피네프린과 같은 카테콜라민, 코티졸, 테스토스테론 그리고 성장호르몬 등은 스트레스에 예민한 반응을 보인다. 한편 스트레스 연구를 위한 타액표본은 혈액이나 요의 표본과는 달리 스트레스를 주지 않고도 표본을 얻을 수 있으며 신체적인 구속이나 윤리적인 문제 등을 염려하지 않고도 채취가 가능하다는 장점이 있다. 타액내의 호르몬의 수치는 혈액내의 호르몬 수치를 잘 반영하므로 스트레스와 관련된 구강안면통증의 연구에 있어서 타액내의 스트레스 호르몬에 활용도는 매우 높으리라고 사료된다.

Keywords

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