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Morphology Development of HAp Crystallites in GEL Matrix

  • Chang, Myung-Chul (School of Materials Science and Chemical Engineering, Kunsan National University)
  • Published : 2007.03.31

Abstract

The crystal morphology of hydroxyapatite [HAp] phase in gelatin [GEL] matrices was investigated with the condition of a GEL precursor treatment in an aqueous solution of $H_{3}PO_{4}$ at $37-80^{\circ}C$. Needle-shaped nanocomposite particles were prepared through a dynamic reaction during a coprecipitation process using a phosphoric GEL solution. Various types of mineralized morphology appeared with a phosphorylated condition of the GEL solution. HAp/GEL nanocomposite slurries showed the existence of an octacalcium phosphate [OCP] phase during the process.

Keywords

References

  1. R. A. Young, 'Biological Apatite vs. Hydroxyapatite at the Atomic Level,' Clinical Orthopedics, 113 249-60 (1975) https://doi.org/10.1097/00003086-197511000-00036
  2. S. Mann, D. D. Archibald, J. M. Didymus, T. Douglas, B. R. Heywood, F. C. Meldrum, and J. R. Nicholas, 'Crystallization at Inorganic-Organic Interfaces: Biomaterials and Biomimetic Synthesis,' Nature, 382 313-18 (1993) https://doi.org/10.1038/382313a0
  3. M.C.Chang, T. Ikoma, M. Kikuchi, and J. Tanaka, ' Preparation of a Porous Hydroxyapatite/Collagen Nanocomposite Using Glutaraldehyde as a Crosslinkage Agent,' J. Mat. Sci. Lett., 20 [13] 1129-201 (2001) https://doi.org/10.1023/A:1010914621089
  4. M. C. Chang, T. Ikoma, M. Kikuchi, and J. Tanaka, 'The Cross-Linkage Effect of Hydroxyapatite/Collagen Nanocomposites on a Self-Organization Phenomenon,' J. Mat.Sci. Mat. Med., 13 993-97 (2002) https://doi.org/10.1023/A:1019825132610
  5. M. C. Chang and J. Tanaka, 'FT-IR Study for Hydroxyapatite/ Collagen Nanocomposite Cross-Linked by Glutaraldehyde,' Biomaterials, 23 3879-85 (2002) https://doi.org/10.1016/S0142-9612(02)00232-6
  6. M. C. Chang and J. Tanaka, 'XPS Study for the Microstructure Development of Hydroxyapatite Collagen Nanocomposites Cross-Linked Using Glutaraldehyde,' Biomaterials, 23 4811-18 (2002) https://doi.org/10.1016/S0142-9612(02)00133-3
  7. F. Peters and M. Epple, 'Crystallization of Calcium Phosphates under Constant Conditions with a Double Diffusion Set-Up,' J. Chem. Soc. Dalton Trans., 24 3585-92 (2001) https://doi.org/10.1039/b106986c
  8. M. C. Chang, C.-C. Ko, and W. H. Douglas, 'Preparation of Hydroxyapatite-Gelatin Nanocomposite,' Biomaterials, 24 2853-62 (2002) https://doi.org/10.1016/S0142-9612(03)00115-7
  9. M. C. Chang, C.-C. Ko, and W. H. Douglas, 'Conformational Change of Hydroxyapatite/Gelatin Nanocomposite by Glutaraldehyde,' Biomaterials, 24 3087-94 (2002) https://doi.org/10.1016/S0142-9612(03)00150-9
  10. M. C. Chang, J. Tanaka, and W. H. Douglas, 'Organic-Inorganic Interaction and the Growth Mechanism of Hydroxyapatite Crystals in Gelatin Matrices between 37 and $80^{\circ}C$,' J. Mat. Sci. Mat. Med., 17 387-96 (2006) https://doi.org/10.1007/s10856-006-8243-9
  11. A. G. Word and A. Courts, 'The Science and Technology of Gelatin,' Academic Press, London, 1977
  12. M. Iijima, 'Monogr. Oral. Sci., Octacalcium Phosphate; Formation of Octacalcium Phosphate in vitro,' Vol. 15, p. 17-49, Kager, Basel., 2001 https://doi.org/10.1159/000061647
  13. M. C. Chang, 'Biomimetic Nanocomposite,' US Patent Application, 2005