Toxicological Research

  • 제23권1호
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  • Pages.47-53
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  • 2007
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
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Amygdalin의 in Vitro 분해에 관한 연구

A Study on the Decomposition of Amygdalin Using an In Vitro Assay

  • 권훈정 (서울대학교 생활과학대학 식품영양학과) ;
  • 조용진 (서울대학교 생활과학대학 식품영양학과)
  • Kwon, Hoon-Jeong (Department of Food and Nutrition, College of Human Ecology, Seoul National University) ;
  • Jo, Yong-Jin (Department of Food and Nutrition, College of Human Ecology, Seoul National University)
  • 발행 : 2007.03.31
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초록

Amygdalin is a cyanogenic glycoside which is commonly found in almonds, bamboo shoots, and apri-cot kernels, and peach kernels. Amygdalin was first hydrolysed into prunasin, then degraded into cyanohydrin by sequential two-stage mechanism. The objective of this study was to examine the amygdalin decomposition and cyanide formation at various in vitro conditions, including acid, enzyme and anaerobic microbes (AM) in human feces (HF). In acid hydrolysis mimicking gastric environment, amygdalin was degraded to cyanide up to 0.2% in specific pH. In contrast, enzyme assay showed higher cyanide generation either by ${\beta}$-glucosidase, or by incubation with microbe. In conclusion, we are convinced of cyanide generation are occurred mainly by microbiological activities of the gut flora up to 41.53%. After ingestion with some staff, the degree and site of degradation in an organism is a key parst of regulatory decision making of that staff.

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