Korean Journal of Materials Research (한국재료학회지)

Materials Research Society of Korea (한국재료학회)
권호 표지
DOI QR코드

DOI QR Code

Biocompatibility of Low Modulus Porous Titanium Implants Fabricated by Spark Plasma Sintering

방전플라즈마소결법에 의해 제조된 저탄성 타이타늄 다공질체의 생체적합성 평가

  • Song, Ho-Yeon (Department of Microbiology School of Medicine, Soonchunhyang University) ;
  • Kim, Young-Hee (Department of Microbiology School of Medicine, Soonchunhyang University) ;
  • Chang, Se-Hun (Korea Institute of industrial Technology(KITECH), Gwangju Research Center) ;
  • Oh, Ik-Hyun (Korea Institute of industrial Technology(KITECH), Gwangju Research Center)
  • 송호연 (순천향대학교 의과대학) ;
  • 김영희 (순천향대학교 의과대학) ;
  • 장세훈 (한국생산기술연구원 광주연구센터) ;
  • 오익현 (한국생산기술연구원 광주연구센터)
  • Published : 2007.02.27
Download PDF
⟨ Previous Next ⟩

Abstract

Porous Ti compacts were fabricated by spark plasma sintering (SPS) method and their in vitro and in vivo biocompatibilities were investigated. Alkaline phosphatase (ALP) activity representing the activity of osteoblast was increased when osteoblast-like MG-63 cells were cultured on the Ti powder surface. Some genes related to cell growth were over-expressed through microarray analysis. The porous Ti compact with 32.2% of porosity was implanted in the subcutaneous tissue of rats to confirm in vivo cytotoxicity. 12 weeks post-operation, outer surface and inside the porous body was fully filled with fibrous tissue and the formation of new blood vessels were observed. No inflammatory response was confirmed. To investigate the osteoinduction, porous Ti compact was implanted in the femur of NZW rabbits for 4 months. Active in-growth of new bone from the surrounded compact bone was observed around the porous body. From the results, The porous Ti compacts fabricated by spark plasma sintering might be available for the application of the stem part of artificial hip joint.

Keywords

References

  1. D. S. Hwang, A. S. Shanbhang, H. O. Bailey and H. E. Rubash, J. Kor. Hip. Soc., 7, 149 (1995)
  2. K. Kieswetter, Z. Schwartz, T. W. Hummert, D. L. Cochran, J. Simpson, D. D. Dean and B. D. Boyan, J. Biomed. Mater. Res., 32, 55 (1996) https://doi.org/10.1002/(SICI)1097-4636(199609)32:1<55::AID-JBM7>3.0.CO;2-O
  3. M. Wagner and H. Wagner, Clin. Orthop., 379, 123 (2000) https://doi.org/10.1097/00003086-200010000-00015
  4. J. P. Garino, Clin. Orthop., 379, 41 (2000) https://doi.org/10.1097/00003086-200010000-00007
  5. L. Sedel, Clin. Orthop., 379, 48 (2000) https://doi.org/10.1097/00003086-200010000-00008
  6. L. Sedel, P. Bizot, R. Nizard and A. Meunier, Semin. Arthroplasty, 9, 123 (1998)
  7. M. Winter, P. Griss and G. Scheller, Clin. Orthop., 282, 73 (1992)
  8. B. Y. Li, L. J. Long, Y. Y. Li and V. E. Gjunter, Acta Mater., 48, 38 (2000)
  9. D. Kuroda, M. Minomi, M. Morinaga, Y. Kato and T. Yashiro, Mater. Sci. Eng., 243, 2 (1989)
  10. Y. Okazaki, E. Nishimura, H. Nakada and K. Kobayashi, Biomaterials., 22, 5 (2001) https://doi.org/10.1016/S0142-9612(00)00221-0
  11. M. Long and H. J. Rack, Biomaterials., 19, 16 (1998) https://doi.org/10.1016/S0142-9612(97)00146-4
  12. E. Whiteside, Clin. Orthop., 248, 2 (1998)
  13. I. H. Oh, H. T. Son, S. H. Chang, H. M. Kim, K. Y. Lee, S. S. Park and H. Y. Song, J. Kor. Inst. Met & Mater, 44, 6 (2006)
  14. M. Thieme, K. P. Witeter, F. Bergner, D. Scharnweber, H. Worch and J. Ndop, Mater. Sci. Forum., 308, 3 (1999) https://doi.org/10.4028/www.scientific.net/MSF.308-311.374

Cited by

  1. Effect of CaCl2 on Microstructure of Calciothermic Reduction Products of Ti2O3 to Prepare Porous Titanium vol.8, pp.9, 2018, https://doi.org/10.3390/met8090698