Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Nitrogen Control in Corynebacterium glutamicum: Proteins, Mechanisms, Signals

  • Burkovski, Burkovski (Lehrstuhl fur Mikrobiologie, Friedrich-Alexander-Universital Erlangen-Nurnberg) ;
  • Andreas, Andreas (Lehrstuhl fur Mikrobiologie, Friedrich-Alexander-Universital Erlangen-Nurnberg)
  • Published : 2007.02.28
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Abstract

In order to utilize different nitrogen sources and to survive in a situation of nitrogen limitation, microorganisms have developed sophisticated mechanisms to adapt their metabolism to a changing nitrogen supply. In this communication, the recent knowledge of nitrogen regulation in the amino acid producer Corynebacterium glutamicum is summarized. The core adaptations of C. glutamicum to nitrogen limitation on the level of transcription are controlled by the global regulator AmtR. Further components of the signal pathway are GlnK, a $P_{II}-type$ signal transduction protein, and GlnD. Mechanisms involved in nitrogen control in C. glutamicum regulating gene expression and protein activity are repression of transcription, protein-complex formation, protein modification by adenylylation, change of intracellular localization, and proteolysis.

Keywords

References

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