참고문헌
- Tachikawa, E. et al. In vitro inhibition of adrenal catecholamine secretion by steroidal metabolites of ginseng saponins. Biochem Pharmacol 66:2213-2221 (2003) https://doi.org/10.1016/j.bcp.2003.07.012
- Lee, Y. et al. A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. J Steroid Biochem Mol Biol 84:463-468 (2003) https://doi.org/10.1016/S0960-0760(03)00067-0
- Bae, E. A. et al. Ginsenosides Rg3 and Rh2 inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferon-gamma stimulated BV-2 microglial cells. Planta Med 72:627-633 (2006) https://doi.org/10.1055/s-2006-931563
- Jung, S. H. et al. Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase- 9 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathways in human astroglioma cells. Int J Cancer 118:490-497 (2006) https://doi.org/10.1002/ijc.21356
- Lee, S. J. et al. Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease. Biochem Pharmacol 60:677-685 (2000) https://doi.org/10.1016/S0006-2952(00)00362-2
- Ambs, S. et al. Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. Cancer Res 58:334-341 (1998)
- Cianchi, F. et al. Inducible nitric oxide synthase expression in human colorectal cancer: correlation with tumor angiogenesis. Am J Pathol 162:793-801 (2003) https://doi.org/10.1016/S0002-9440(10)63876-X
- Ambs, S. et al. Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice. Proc Natl Acad Sci USA 95:8823-8828 (1998)
- Li, J., Billiar, T. R., Talanian, R. V. & Kim, Y. M. Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation. Biochem Biophys Res Commun 240:419-424 (1997) https://doi.org/10.1006/bbrc.1997.7672
- Oh, G. S. et al. 20 (S)-Protopanaxatriol, one of ginsenoside metabolites, inhibits inducible nitric oxide synthase and cyclooxygenase-2 expressions through inactivation of nuclear factor-kappaB in RAW 264.7 macrophages stimulated with lipopolysaccharide. Cance Lett 205:23-29 (2004) https://doi.org/10.1016/j.canlet.2003.09.037
- Helms, S. Cancer prevention and therapeutics: Panax ginseng. Altern Med Rev 9:259-274 (2004)
- Oh, S. H. & Lee, B. H. A ginseng saponin metabolite- induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage. Toxicol Appl Pharmacol 194:221-229 (2004) https://doi.org/10.1016/j.taap.2003.09.011
- Li, G. et al. Ginsenoside 20(S)-protopanaxadiol inhibits the proliferation and invasion of human fibrosarcoma HT1080 cells. Basic Clin Pharmacol Toxicol 98:588-592 (2006) https://doi.org/10.1111/j.1742-7843.2006.pto_415.x
- Ming, Y. L. et al. Anti-proliferation and apoptosis induced by a novel intestinal metabolite of ginseng saponin in human hepatocellular carcinoma cells. Cell Biol Int 31:1265-1273 (2007) https://doi.org/10.1016/j.cellbi.2007.05.005
- Wakabayashi, C. et al. An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem Biophys Res Commun 246:725-730 (1998) https://doi.org/10.1006/bbrc.1998.8690
- Thomsen, L. L. et al. Nitric oxide synthase activity in human gynecological cancer. Cancer Res 54:1352- 1354 (1994)
- Zhang, R., Ma, A., Urbanski, S. J. & McCafferty, D. M. Induction of inducible nitric oxide synthase: a protective mechanism in colitis-induced adenocarcinoma. Carcinogenesis 28:1122-1130 (2007) https://doi.org/10.1093/carcin/bgl224
- Jenkins, D. C. et al. Roles of nitric oxide in tumor growth. Moncada SProc Natl Acad Sci USA 92:4392- 4396 (1995)
- Rao, C. V., Kawamori, T., Hamid, R. & Reddy, B.S. Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor. Carcinogenesis 20:641-644 (1999) https://doi.org/10.1093/carcin/20.4.641
- DeRisi, J. et al. Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nat Genet 14:457-460 (1996) https://doi.org/10.1038/ng1296-457
- Cheadle, C., Vawter, M. P., Freed, W. J. & Becker, K. G. Analysis of microarray data using Z score transformation. J Mol Diagn 5:73-81 (2003) https://doi.org/10.1016/S1525-1578(10)60455-2
- Eisen, M. B., Spellman, P. T., Brown, P. O. & Botstein, D. Cluster analysis and display of genomewide expression patterns. Proc Natl Acad Sci USA 95:14863-14868 (1998)
- Lee, S.J. et al. Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome cmediated activation of caspase-3 protease. Biochem Pharmacol 60:677-658 (2000) https://doi.org/10.1016/S0006-2952(00)00362-2