Molecular & Cellular Toxicology

The Korean Society of Toxicogenomics and Toxicoproteomics (대한독성유전 단백체학회)
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The Efficiency of Zinc-Aspartate Complex on Zinc Uptake in Plasma and Different Organs in Normal SD Rats

  • Kim, Yu-Ri (Department of Biochemistry & Molecular biology, Korea University Medical College) ;
  • Kim, Ki-Nam (Department of Biochemistry & Molecular biology, Korea University Medical College) ;
  • Shim, Boo-Im (Department of Biochemistry & Molecular biology, Korea University Medical College) ;
  • Lee, Seung-Min (Department of Biochemistry & Molecular biology, Korea University Medical College) ;
  • Kim, In-Kyoung (Department of Biochemistry & Molecular biology, Korea University Medical College) ;
  • Sohn, Sung-Hwa (Department of Biochemistry & Molecular biology, Korea University Medical College) ;
  • Park, Myung-Gyu (MD BioAlpha Co., Ltd) ;
  • Park, Hong-Suk (Department of Urology, College of Medicine, Korea University) ;
  • Kim, Meyoung-Kon (Department of Biochemistry & Molecular biology, Korea University Medical College)
  • Published : 2007.06.30
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Abstract

Zinc is essential metal and plays a role in a wide variety of physiological and biochemical processes. Prostate gland contains high level of zinc, generally 3-10 folds higher than other organs. Prostatic zinc uptake is resulted from the existence of zinc transporter (ZnT) protein families in membrane. In this study, we investigated the difference of zinc uptake efficiency of zinc-aspartate complex (Zn-Asp) into various organs compared with $ZnSO_4$. We observed that Plasma zinc concentration in both $ZnSO_4$ and Zn-Asp administrated group was increased progressively following administration, and reached a peak level at 2 hr. The increasing pattern of zinc concentration was similar to each groups, however the zinc concentration of Zn-Asp administrated group was higher than that of $ZnSO_4$ administrated group. We found that prostatic zinc level of Zn-Asp administrated group was higher than $ZnSO_4$ administrated group, and was increased approximately $\sim$2.7 fold and $\sim$4.2 fold at 4 and 8 hr after administration. From these observations, we suggest than Zn-Asp has high uptake efficiency of zinc into the prostate gland. Therefore, Zn-Asp is potentially useful treatment of many prostatic diseases.

Keywords

References

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