Investigative and Clinical Urology

  • 제48권7호
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  • Pages.741-747
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  • 2007
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  • 2466-0493(pISSN)
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  • 2466-054X(eISSN)
대한비뇨의학회 (The Korean Urological Association)
권호 표지

산수유 복합 추출 분말이 발기 부전증 환자에 미치는 임상적 효과와 안전성

Efficacy and Safety of a Herbal Formula that Mainly Consists of Cornus Officinalis for Erectile Dysfunction: A Double-blind, Placebo-controlled Study

감성철;최세민;제성욱;이승현;화정석;정기현;강창완;현재석
Kam, Sung-Chul;Choi, See-Min;Jeh, Sung-Uk;Lee, Seung-Hyun;Hwa, Jeong-Seok;Jung, Ky-Hyun;Kang, Chang-Wan;Hyun, Jae-Seog

  • 발행 : 20070700
⟨ 이전 논문 다음 논문 ⟩

초록

The aim of this study was to evaluate the efficacy and safety of a herbal formula that mainly consists of Cornus officinalis for treating erectile dysfunction. Materials and Methods: Eighty patients suffering with erectile dysfunction were enrolled in this randomized, double-blinded, placebo-controlled study. The average duration of erectile dysfunction of the herbal formula group(n=40) vs. the placebo group(n=40) were 19.33±18.13 months vs. 19.33±25.62 months, respectively. The safety variables we examined were the history, physical examination, vital signs, EKG, clinical laboratory tests and hormonal tests. Efficacy assessments included the International Index of Erectile Function(IIEF), the sexual encounter profile(SEP) diary and Global Assessment Questions(GAQ). Results: No significant changes in the laboratory values, hormone tests and blood pressure were observed in both groups. In comparison with the placebo group(6.57±11.72), the herbal formula group experienced a significant improvement of the IIEF(11.13±11.83)(p＜0.05). When the herbal formula and placebo groups were divided by age and the IIEF score (age: 50 years and IIEF: 42) and then compared, the low IIEF group(IIEF≤42) and old age group(age≥50) of the herbal formula group significantly improved their IIEF score(p＜0.05). The herbal formula group significantly improved their GAQ score(p＜0.05). The herbal formula was well tolerated. The common adverse events were headache(2.5%) and nausea(5%). Conclusions: In conclusion, the herbal formula that mainly consists Cornus officinalis was not only effective at improving erectile function, but it was also safe for the treatment of erectile dysfunction.

키워드

참고문헌

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