마우스에서 SureDerm®, Permacol® 이식 생존에 대한 비교

Comparison of Survival of SureDerm®, Permacol® Graft in Mouse

  • 홍정수 (중앙대학교 의과대학 성형외과학교실) ;
  • 김우섭 (중앙대학교 의과대학 성형외과학교실) ;
  • 유영일 (유영일 성형외과) ;
  • 김한구 (중앙대학교 의과대학 성형외과학교실)
  • Hong, Jung Soo (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University) ;
  • Kim, Woo Seob (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University) ;
  • Yu, Young Il (Yu Young Il Plastic Surgery Clinics) ;
  • Kim, Han Koo (Department of Plastic and Reconstructive Surgery, College of Medicine, Chung-Ang University)
  • 투고 : 2007.03.25
  • 발행 : 2007.11.10

초록

Purpose: Numerous materials, both autologous and nonautologous, have been used for augmentation of sunken areas and each has its own limitations. The ideal material for augmentation should not be absorbed in any manner. This study is designed to assess the survival of $SureDerm^{(R)}$, $Permacol^{(R)}$ graft according to the volume and histologic change. Methods: Twenty four mice, weighing about 50 grams and of 5 weeks of age were used. $SureDerm^{(R)}$ is an acellular dermal matix obtained from human cadeveric skin. $Permacol^{(R)}$ is a porcine derived acellular dermal matrix whose manufacture involves trypsinisation, solvent extraction. Graft pieces standardized to $1{\times}1cm$ size were used in each group. The implanted material were taken 1, 4, 8 and 12 weeks later, respectively. The changes of graft volume during the graft period were measured on initial, 1, 4, 8 and 12 weeks. Results: The initial shape of graft was maintained up to 12 weeks in $Permacol^{(R)}$ graft group and mean survival rate was $80.36{\pm}8.21%$ in $SureDerm^{(R)}$, $89.57{\pm}6.39%$ in $Permacol^{(R)}$(p=0.01). The volume of each graft decreased 29% from initial volume on 12 weeks in $SureDerm^{(R)}$, 18% in $Permacol^{(R)}$. The structure of $Permacol^{(R)}$ remained until 12 week after implantation. Conclusion: Our experimental study suggests that $Permacol^{(R)}$ could be a safe material as an implant for permanent augmentation. However, There are further study remained for antigenicity of these material, and the choice of graft for augmentation should be remained to the clinical situations.

키워드

과제정보

연구 과제 주관 기관 : 중앙대학교

참고문헌

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