Analytical Science and Technology (분석과학)

The Korean Society of Analytical Sciences (한국분석과학회)
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Proficiency test for analyzing illegal compounds in food

식품 중 부정유해물질의 분석 능력평가

  • Chang, Moonik (Food Evaluation Department, Korea Food & Drug Administration) ;
  • Yoon, Taehyung (Food Evaluation Department, Korea Food & Drug Administration) ;
  • Hong, Mooki (Food Evaluation Department, Korea Food & Drug Administration) ;
  • Choi, Dongmi (Food Evaluation Department, Korea Food & Drug Administration)
  • 장문익 (식품의약품안전청, 식품평가부) ;
  • 윤태형 (식품의약품안전청, 식품평가부) ;
  • 홍무기 (식품의약품안전청, 식품평가부) ;
  • 최동미 (식품의약품안전청, 식품평가부)
  • Received : 2006.12.08
  • Accepted : 2007.01.18
  • Published : 2007.02.28
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Abstract

To perform proficiency test for determining anti-impotence drug-like compounds in food, interlaboratory test has been done. Targets were 6 such as sildenafil, tadalafil, vardenafil, homosildenafil, hydroxy-homosildenafil and pseudo-vardenafilI. Total 13 institutes were participated and all is in charging of food analysis. To do double blind test, the reference materials were made as 13 different ginseng drink samples and each sample had random 3 targets. By the official method for anti-impotence drug-like compounds in food code, sample was just diluted in water, extracted in organic solvents, determined by HPLC/UV and then confirmed by LC/MS. The analytical duration was 60 days after receiving sample. Ten out of 13 institutes were satisfied by evaluation of Z-score and RSZ according to the regulation for managing analytical quality assurance.

식품 중 발기부전치료 성분 및 유사물질의 분석능력을 평가하기 위하여 실험실간 정도관리를 시도하였다. 평가대상물질은 실데나필, 타다라필, 바데나필, 호모실데나필, 하이드록시호모실데나필, 슈도바데나필 6종이었으며, 참여기관은 식품위생검사를 담당하고 있는 13개 기관이었다. 표준시료는 이중맹검을 위하여 평가대상물질 중 임의의 3종을 함유하도록 조제한 인삼음료 13개이었다. 분석방법은 식품공전의 일반시험법에 제시되어 있는 발기부전치료제 유사물질 시험법에 따라 일정량을 취하여 물에 희석한 후 유기용매로 추출하여 HPLC/UV로 분석하고 LC/MS로 확인하는 방법을 적용하였다. 분석기간은 표준시료를 수령한 날로부터 60일이었다. 검사능력관리규정에 따라 Z-값 및 RSZ를 종합평가한 결과 10기관이 만족한 수준이었다.

Keywords

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