구강회복응용과학지 (Journal of Dental Rehabilitation and Applied Science)

  • 제23권2호
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  • Pages.179-186
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  • 2007
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  • 2384-4353(pISSN)
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  • 2384-4272(eISSN)
대한턱관절교합학회 (Korean Academy of Stomatognathic Function and Occlusion)
권호 표지

구치부 치관삭제가 생쥐 해마복합체에 미치는 영향에 관한 조직학적 연구

Influence of Molarless Condition on the Hippocampal Formation in Mouse: a Histological Study

  • 김용철 (조선대학교 치과대학 보철학 교실) ;
  • 강동완 (조선대학교 치과대학 보철학 교실)
  • Kim, Yong-Chul (Department of Prothodontics, College of Dentistry, Chosun University) ;
  • Kang, Dong-Wan (Department of Prothodontics, College of Dentistry, Chosun University)
  • 발행 : 2007.06.30
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초록

The decrease of masticatory function caused by tooth loss leads to a decrease of cerebral blood flow volume resulting in impairment of cognitive function and learning memory disorder. However, the reduced mastication-mediated morphological alteration in the central nervous system (CNS) responsible for senile deficit of cognition, learning and memory has not been well documented. In this study, the effect of the loss of the molar teeth (molarless condition) on the hippocampal expression of glial fibrillary acidic protein (GFAP) protein was studied by immunohistochemical techniques. The results were as follows : 1. The molarless mice showed a lower density of pyramidal cells in the cornu ammonis 1 (CA1) and dentate gyrus (DG) region of the hippocampus than control mice. 2. Immunohistochemical analysis showed that the molarless condition enhanced the time-dependent increase in the cell density and hypertrophy of GFAP immunoreactivity in the CA1 region of the hippocampus. The molarless condition enhanced an time-dependent decrease in the number of neurons in the hippocampal formation and the time-dependent increase in the number and hypertrophy of GFAP-labeled cells in the same region. The data suggest a possible link between reduced mastication and histological changes in hippocampal formation that may be one risk factor for senile impairment of cognitive function and spatial learning memory.

키워드

과제정보

연구 과제 주관 기관 : 조선대학교

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