Influence of Molarless Condition on the Hippocampal Formation in Mouse: a Histological Study

구치부 치관삭제가 생쥐 해마복합체에 미치는 영향에 관한 조직학적 연구

  • Kim, Yong-Chul (Department of Prothodontics, College of Dentistry, Chosun University) ;
  • Kang, Dong-Wan (Department of Prothodontics, College of Dentistry, Chosun University)
  • 김용철 (조선대학교 치과대학 보철학 교실) ;
  • 강동완 (조선대학교 치과대학 보철학 교실)
  • Published : 2007.06.30

Abstract

The decrease of masticatory function caused by tooth loss leads to a decrease of cerebral blood flow volume resulting in impairment of cognitive function and learning memory disorder. However, the reduced mastication-mediated morphological alteration in the central nervous system (CNS) responsible for senile deficit of cognition, learning and memory has not been well documented. In this study, the effect of the loss of the molar teeth (molarless condition) on the hippocampal expression of glial fibrillary acidic protein (GFAP) protein was studied by immunohistochemical techniques. The results were as follows : 1. The molarless mice showed a lower density of pyramidal cells in the cornu ammonis 1 (CA1) and dentate gyrus (DG) region of the hippocampus than control mice. 2. Immunohistochemical analysis showed that the molarless condition enhanced the time-dependent increase in the cell density and hypertrophy of GFAP immunoreactivity in the CA1 region of the hippocampus. The molarless condition enhanced an time-dependent decrease in the number of neurons in the hippocampal formation and the time-dependent increase in the number and hypertrophy of GFAP-labeled cells in the same region. The data suggest a possible link between reduced mastication and histological changes in hippocampal formation that may be one risk factor for senile impairment of cognitive function and spatial learning memory.

Keywords

Acknowledgement

Supported by : 조선대학교

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