Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
권호 표지

A HISTOMORPHOMETRIC STUDY OF BONE FORMATION AROUND IMPLANTS PLACED AFTER VERTICAL ALVEOLAR DISTRACTION IN THE DOG MEDEL

치조골신장 부위에 식립된 임프란트 주위의 골형성에 관한 연구

  • Park, Jong-Oh (Department of Oral and Maxillofacial Surgery, Division of Dentistry Graduate School, KyungHee University) ;
  • Rhu, Dong-Mok (Department of Oral and Maxillofacial Surgery, Division of Dentistry Graduate School, KyungHee University)
  • 박종오 (경희대학교 대학원 치의학과 구강악안면외과학교실) ;
  • 류동목 (경희대학교 대학원 치의학과 구강악안면외과학교실)
  • Published : 2007.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose: Distraction osteogenesis has been applied to the maxillofacial implantology and good experimental and clinical results have been reported. However, histologic studies of implants placement on distraction osteogenesis of atrophic alveolar ridges are scarce. In this study, we compare the bone formation between in the transport part and in the distraction part by histomorphometric analysis. Materials & methods: Three adult beagle dogs were served as experimental subjects. The 2 premolars and 1st molar were extracted on the Lt. side of mandible in each beagle dog. After one month later, osteotomy was performed and distraction device was adapted. Distraction was performed with gradual incremental separation of two bone pieces at a rate of 1.0mm per day for 5 days. During consolidation phase, new bone was formed in the distraction zone between the separated bone pieces. 5 weeks after distraction phase, 3 implants were placed in each beagle dog. The implants were inserted through transport part and distraction part and inferior basal bone. The animals were sacrificed at 2 weeks, 4 weeks, and 12 weeks after implant placement. BIC and BA of implants on distraction part and transport part were measured histomorphometrically. Results: BIC, BA increased after implant placement as time goes by passes and new bone formation was slightly higher in transport part than in distraction part at 2 weeks, 4 weeks after implant placement. At 12 weeks after implant placement, BIC, BA of were 74%, 61% in transport part and 77%, 59% in distraction part, therefore there were no difference in BIC and BA between transport part and distraction part at 12 weeks after implant placement.

Keywords

References

  1. Ilizarov GA: A new principle of osteosynthesis with the use of crossing pins and rings. In Collection of Scientific Works of the Kurgn Regional Scientific Medical Society. Kurgan, USSR,. 1954:145
  2. McCarthy JG, Schreiberg N, Karp CH et al: Lengthening of the human mandible by gradual distraction. Plast Reconstr Surg 1992;89:1 https://doi.org/10.1097/00006534-199205000-00018
  3. Ilizarov GA: The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft tissue preservation. Clin Orthop 1989:238-249
  4. Ilizarov GA: The tension-stress effect on the genesis and growth of tissues. Part II. The influence of the rate and frequency of distraction. Clin Orthop 1989:239-263
  5. Kojimoto H, Yasui N, Goto T, Matsuda S, Shimomura Y: Bone lengthening in rabbits by callus distraction : The role of periosteum and endosteum. J Bone Joint Surg 1988;70:543
  6. Kokala O, Karaharju E, Gronblad M, Aalto K: Experimental lengthening of tibial diaphysis : Gap healing with or without gradual distraction. Arch Ortho Trauma Surg 1998:107-172
  7. Karp NS, Thorne CH, McCarthy JG, Sissons HA: Bone lengthening in the craniofacial skeleton. Ann Plast Surg 1990;24:231 https://doi.org/10.1097/00000637-199003000-00007
  8. Costantino PD, Freidman CS: Experimental mandiular regrowth by distraction osteogenesis. Arch Otolaryngol Head Neck Surg 1993; 119:511 https://doi.org/10.1001/archotol.1993.01880170035007
  9. Tavakoli K, Walsh WR, Bonar F, Smart R, Wulf S, Poole MD: The role of latency in mandibular osteodistraction. J Craniofac Surg 1999;26:209
  10. Aronson J, Shen XC, Skinner RA, Hogue WR, Badger TM, Lumpkin CK Jr.: Rat model of distraction osteogenesis. J Orthop Res 1997;15:221 https://doi.org/10.1002/jor.1100150210
  11. Troulis MJ, Glowacki J, Perrot DH, Kaban LB: Effects of latency and rate on bone formation in a porcrine mandibular distraction model. J Oral Maxillofac Surg 2000;58:507 https://doi.org/10.1016/S0278-2391(00)90012-0
  12. Paccione MF, Mehrara BJ, Warren SM, Greewald JA, Spector JA, Luchs JS, Longaker MT: Rat mandibular distraction osteogenesis : latency, rate, and rhythm determine the adaptive response. J Craniofac Surg 2001;12:175 https://doi.org/10.1097/00001665-200103000-00015
  13. Aida T, Yoshioka I, Tominaga K, Fukuda J: Effects of latency period in a rabbit mandibular distraction osteogenesis. Int J Oral Maxillofac Surg 2003;32:54
  14. 장건택, 오정환, 김여갑: 골신장술시 휴지기간과 골편의 신장방향이 신생골 형성에 미치는 영향. 대한악안면성형재건외과학회지 2004;26:511
  15. Block MS, Chang A, Crawford C: Mandibular alveolar ridge augmentation in the dog using distraction osteogenesis. J Oral Maxillofac Surg 1996;54:309 https://doi.org/10.1016/S0278-2391(96)90750-8
  16. Block MS, Almerico B, Crawford C, Gardiner D, Chang A: Bone response to functioning implants in dog mandibular alveolar ridges augmented with distraction osteogenesis. Int J Oral Maxillofac Implants. 1998;13:342
  17. Nosaka Y, Tsunokuma M, Hayashi H, Kakudo K: Placement of implants in distraction osteogenesis : a pilot study in dogs. Int J Oral Maxillofac Implants 2000;15:185
  18. Gaggl A, Schultes G, Regauer S, Karcher H: Healing process after alveolar ridge distraction in sheep. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90:420 https://doi.org/10.1067/moe.2000.109159
  19. Oda T, Sawaki Y, Ueda M: Experimental alveolar ridge augmentation by distraction osteogenesis using a simple device that permits secondary implant placement. Int J Oral Maxillofac Implants 2000;15:95
  20. Urbani G, Lombardo G, Santi E, Consolo U: Distraction osteogenesis to achieve mandibular vertical bone regeneration : a case report. Int J Periodontics Restorative Dent 1999;19:321
  21. McAllister BS: Histologic and radiographic evidence of vertical ridge augmentation utilizing distraction osteogenesis : 10 consecutively placed distractors. J Periodontol 2001;72:1767 https://doi.org/10.1902/jop.2001.72.12.1767
  22. Zaffe D, Bertoldi C, Palumbo C, Consolo U: Morphofunctional and clinical study on mandibular alveolar distraction osteogenesis. Clin Oral Implants Res 2002;13:550 https://doi.org/10.1034/j.1600-0501.2002.130516.x
  23. Chiapasco M, Romeo E, Vogel G: Vertical distraction osteogenesis of edentulous ridges for improvement of oral implant positioning: a clinical report of preliminary results. Int J Oral Maxillofac Implants 2001;16:43
  24. Urbani G: Alveolar distraction before implantation : a report of five cases and a review of the literature. Int J Periodontics Restorative Dent 2001;21:569
  25. Papageorge MB: Distraction osteogenesis for augmentation of the deficient alveolar ridge. J Mass Den Soc 2002;51:24
  26. Horiuchi K, Uchida H, Yamamoto K, Hatano N: Anteroinferior distraction of the atrophic subtotal maxillary alveolus for implant placement : a case report. Int J Oral Maxillofac Implants 2002;17:416
  27. Lin Y, Wang X, Li J, Qiu L, Chen B: Clinical study of alveolar vertical distraction osteogenesis for implant. Zhonghua Kou Qiang Yi Xue Za Ahi 2002;37:253
  28. Hurzeler MB, Zuhr O, Schenk G, Schoberer U, Wachtel H, Bolz W: Distraction osteogenesis : a treatment tool to improve baseline conditions for esthetic restorations on immediately placed dental implants : a case report. Int J Periodontics Restorative Dent 2002;22:451
  29. Raghoebar GM, Liem RS, Vissink A: Vertical distraction of the severely resorbed edentulous mandible : a clinical, histological and electron microscopic study of 10 treated cases. Clin Oral Implants Res 2002;13:558 https://doi.org/10.1034/j.1600-0501.2002.130517.x
  30. Degidi M, Pieri F, Marchetti C, Piattelli A: Immediate loading of dental implants placed in distracted bone : a case. Int J Oral Maxillofac Implants 2004;19:448
  31. Ley J, Cranin AN: Distraction osteogenesis for augmenting the dificient alveolar ridge in preparation for dental implant placement : a case report. J Oral Implantol 2004;30:14 https://doi.org/10.1563/1548-1336(2004)030<0014:DOFATD>2.0.CO;2
  32. 오정환, 이정우, 김여갑, 류동목, 이백수, 권용대 등: 심한 치조골 흡수가 있는 무치악 결손부에 대하여 치조골 신장술 시행후 임프란트를 이용한 수복. 대한치과이식학회지 2004;23:48
  33. Rachmiel A, Srouji S, Peled M: Alveolar ridge augmentation by distraction osteogenesis. Int J Oral Maxillofac Surg 2001;30:510 https://doi.org/10.1054/ijom.2001.0134
  34. Garcia-Garcia A, Somoza-Martin M, Gandara-Vila P, Saulacic N, Gandara-Rey JM: Alveolar distraction before insertion of dental implants in the posterior mandible. Br J Oral Maxillofac Surg 2003;41:376
  35. Walker DA: Mandibular distraction osteogenesis for endosseous dental implants. J Can Dent Assoc 2005;71:171
  36. Uckan S, Haydar SG, Dolanmaz D: Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;94:561 https://doi.org/10.1067/moe.2002.128023
  37. Gellirich NC, Suarez-Cunqueiro MM, Schon R, Hoffmann M, Schrmm A: Distraction osteogenesis in an anterior mandibular bone defect utilizing lingual periosteal release : a case report. Int J Oral Maxillofac Implants 2004;19:753
  38. 오정환, 최윤모, 김여갑, 류동목, 이백수, 권용대 등: 치조골 신장치조골신장 부위에 식립된 임프란트 주위의 골형성에 관한 연구 319술과 관련된 합병증에 대한 고찰. 대한구강악안면외과학회지 2005;31 별책 1호:226
  39. Cancedda R, Descalza CF, Castagnola P: Chondrocyte differentiation. Int Rev Cytol 1995;159:265 https://doi.org/10.1016/S0074-7696(08)62109-9
  40. Hagiwara T, Bell WH: Effect of electrical stimulation on mandibular destraction osteogenesis. J craniomaxillo Surg 2000;28:12
  41. Karaharju-Suvanto T, Peltonen J, Kahri A, Karaharju EO: Distraction osteogenesis of the mandible. An Experimetal study on sheep. Int Oral Maxillofac Surg 1992;21:118
  42. Komuro Y, Takato T, Harii K, Yonemara Y: The histologic analysis of distraction osteogenesis of the mandible in rabbits. Plast Reconstr Surg 1994;94:152 https://doi.org/10.1097/00006534-199407000-00017
  43. Leung DW, Cachianes G, Kuang WJ: Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989;246:1306 https://doi.org/10.1126/science.2479986
  44. Sheweiki D, Itin A, Soffer D: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992;359:843
  45. Roiser RN, O'Keefe RJ, Kicks DG: The potential role of transforming growth factor beta in fracture healing. Clin Orthop 1998;355:294
  46. KA Al Ruhaimi: Comparison of different distraction rates in the mandible : an experimental investigation. Int J Oral Maxillofac Surg 2001;30:220 https://doi.org/10.1054/ijom.2001.0046
  47. Johannes Hidding, Frank Lazar, Joachim E: Vertical distraction of the alveolar process : A new technique for reconstructing the alveolar ridge. Craniofacial distraction osteogenesis 2001:393
  48. JB Cope, ML Samchukov: Mineralization dynamics of regenerate bone during mandibular osteodistraction. Int J Oral Maxillofac surg 2001;30:234 https://doi.org/10.1054/ijom.2000.0044
  49. JB Cope, ML Samchukov: Regenerate bone formation and remodeling during mandibular osteodistraction. Angle Orthod 2000;70:99
  50. Piattelli M, Scarano A, Paolantonio M, Iezzi G, Petrone G, Piattelli A: Bone response to machined and resorbable blast material titanium implants : An experimental study in rabbits. J Oral Implantol 2002;28:2
  51. Wenerberg A, Ektessabi A, Albrektsson T, Johansson C, Andersson B: A 1-year follow-up of implants of differing surface roughness placed in rabbit bone. Int J Oral Maxillofac Implants 1997;12:486
  52. Sanz A, Oyarzun A, Farias D, Diaz I: Experimental study of bone response to a new surface treatment of endosseous titanium implants. Implant Dent 2001;10:126 https://doi.org/10.1097/00008505-200104000-00009
  53. Zechner W, Tangl S, Furst G, Tepper G, Thams U, Mailath G, Watzek G: Osseous healing characteristics of three different implant types. Clin Oral Implants Res 2003;14:150 https://doi.org/10.1034/j.1600-0501.2003.140203.x
  54. 홍후석, 김태희, 류승희, 국민석, 박홍주, 오희균: 성견 경골에서 표면처리방법이 다른 4종의 임프란트 골유착에 관한 비교연구. 대한구강악안면외과학회지 2005;31:46