악골에 발생한 법랑아세포종의 임상적 연구

CLINICAL STUDY OF AMELOBLASTOMA ON THE JAW

  • 김현섭 (전남대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 류재영 (전남대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 유민기 (전남대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 서일영 (전남대학교 치의학전문대학원 구강악안면외과학교실) ;
  • ;
  • 국민석 (전남대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 박홍주 (전남대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 유선열 (전남대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 최홍란 (전남대학교 치의학전문대학원 구강병리학교실, 치의학연구소) ;
  • 오희균 (전남대학교 치의학전문대학원 2단계 BK 21)
  • Kim, Hyun-Syeob (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Ryu, Jae-Young (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Yu, Min-Gi (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Seo, Il-Young (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Shet, Uttom Kumar (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Kook, Min-Suk (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Park, Hong-Ju (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Ryu, Sun-Youl (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Choi, Hong-Ran (Departmennt of Oral Pathology, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Oh, Hee-Kyun (Department of School of Dentistry, Chonnam National University, 2nd stage of Brain Korea 21)
  • 발행 : 2007.10.31

초록

Ameloblastoma, a benign tumor of odontogenic type, represents 10% of all tumors of the jaw. It is localized in the mandible(80%) and in the maxilla(20%). In every case, the selection of the surgical treatment must consider some fundamental elements, including the age and general state of health the clinicopathological variant, and the localization and extent of the tumor. This study was invested the clinicopathological findings of 23 patients with ameloblastoma which had been diagnosed by biopsy during the period of 1987 to 2005 at Chonnam National University Hospital. And it contained the statistical analysis according to the treatment methods and the clinicopathological findings such as sex, age, location, chief complaints, duration, radiographic findings, histologic findings, treatment methods. The results obtained are were follows. The age of patient ranged from 10 to 91 years(means, 35.9 years) at biopsy. Thirteen(57%) of the 23 subjects were males, and 10(43%) were females. Twenty(87%) of the 23 ameloblastomas were located in the mandible. Swelling was the most common symptom and was experienced by 20(87%) patients. Radiographically, 11(48%) of the 23 tumors were unilocular with a well-demarcated border and 12(52%) were multilocular. The most common histologic pattern was plexiform and acanthomatous rather then follicular. Conservative treatment was performed 7 cases(30%), radical treatment 11 cases(48%), and combined treatment 5 cases(22%). Follow-up period ranged from 2.1 years to 22 years(mean 5.1 years). Based on the above results, surgical excision after marsupialization was found to be useful as a preliminary treatment of the large cystic ameloblastoma in children and adolescents. On the contrary, the lesion with a soap bubble appearance, the one with ineffective marsupialization was subjected to extensive excision of the tumor with a wide margin of normal bone.

키워드

참고문헌

  1. Small IA, Waldron CA: Ameloblastoma of the jaw. Oral Surg 1955;8:281-297 https://doi.org/10.1016/0030-4220(55)90350-9
  2. Becelli R, Carboni A, Cerulli G: Mandibular Ameloblastoma: Analysis of Surgical Treatment Carried Out in 60 Patients Between 1977 and 1998. J Craniofac Surg 2002;13:395-400 https://doi.org/10.1097/00001665-200205000-00006
  3. Bataineh A, Jordan I: Effect of preservation of the inferior borders on recurrence of ameloblastomas of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90:155-163 https://doi.org/10.1067/moe.2000.107971
  4. Hollows P, Fasamnade A, Hayter JP: Ameloblastoma: a diagnostic problem. Br Dent J 2000;188:243-244 https://doi.org/10.1038/sj.bdj.4800442a
  5. Reichart PA, Philipsen HP, Sonner S: Ameloblastoma: biological profile of 3677 cases. Eur J Cancer B Oral Oncol 1993;31:86-99 https://doi.org/10.1016/0964-1955(94)00037-5
  6. Gardner DG, Pocak AM: The treatment of ameloblastoma based on pathologic and anatomic principles. Cancer 1980;46:2514-2519 https://doi.org/10.1002/1097-0142(19801201)46:11<2514::AID-CNCR2820461133>3.0.CO;2-9
  7. Feinberg E, Steinberg B, Arbor A: Surgical management of ameloblastoma. Current status of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1988;81:383-388 https://doi.org/10.1016/S1079-2104(96)80012-6
  8. Williams TP: Management of ameloblastoma: a changing perspective. J Oral Maxillofac Surg 1993;51:1064-1070 https://doi.org/10.1016/S0278-2391(10)80440-9
  9. Sampson DE, Pogrel MA: Management of mandibular ameloblastoma: the clinical basis for a treatment algorithm. J Oral Maxillofac Surg.1999;57:1074-1077 https://doi.org/10.1016/S0278-2391(99)90328-2
  10. Ueno S, Nakamura S, Mushimoto K, Shirasu R: A clinicopathologic study of ameloblastoma. J Oral Maxillofac Surg 1986;44:361-365 https://doi.org/10.1016/S0278-2391(86)80031-3
  11. Melhisch DR, Dahlin DC, Masson JK: Ameloblastoma: a clinicopathologic report. J Oral Surg 1972;30:9-22
  12. 오명철, 김진수: 법랑아세포종의 치료에 관한 임상통계학적 분석. 대한악안면성형재건외과학회지 1994;15(4):253-268
  13. Goldwyn R, Constable J, Murray JE: Ameloblastoma of the jaw: A clinical study. New England J. Med. 1963;269:126-129 https://doi.org/10.1056/NEJM196307182690303
  14. Kim SG, Jang HS: Ameloblastoma: A clinical, radiographic, and histopathologic anallysis of 71 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:649-653 https://doi.org/10.1067/moe.2001.114160
  15. Shafer WG, Hine MK, Levy BM. A textbook of the oral pathology 4th ed. Philadelphia, W.B. Saunders Co. 1983
  16. Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and maxillofacial pathology 2nd ed. Philadelphia, W.B. Saunders Co. 2002
  17. Nakamura N, Higuchi Y: Marsupialization of cystic ameloblastoma: A clinucal and histopathologic study of the growth characteristics before and after marsupialization 1995;53:748-756 https://doi.org/10.1016/0278-2391(95)90323-2
  18. Nakamura N, Higuchi Y, Mitauyasu T: Comparison of long-term results between different approaches to ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:13-20 https://doi.org/10.1067/moe.2002.119517
  19. Carwley WA, Levin LS: Treatment of the ameloblastoma. Cancer 1978;42:357-363 https://doi.org/10.1002/1097-0142(197807)42:1<357::AID-CNCR2820420154>3.0.CO;2-H
  20. Sehdev MK, Huvos AG, Strong EW, Gerold FP, Willis GW: Ameloblastoma of maxilla and mandible. Cancer 1974;33:324-333 https://doi.org/10.1002/1097-0142(197402)33:2<324::AID-CNCR2820330205>3.0.CO;2-U
  21. Gardner DC, Corio RL: Plexiform unicystic ameloblastoma: A variant of ameloblastoma with a low recurrence rate after enucleation. Cancer 1983;53:1730-1735 https://doi.org/10.1002/1097-0142(19840415)53:8<1730::AID-CNCR2820530819>3.0.CO;2-U
  22. 정영수, 이의웅: 단방낭종성 법랑아세포종의 적출술 후 재발 경향에 관한 연구. 대한구강악안면외과학회지 1998;24:346-353
  23. Isacsson G, Andersson L, Forsslund H, Bodin I, Thompson M: Diagnosis and treatment of unicystic ameloblastoma. Int J Oral maxillofac Surg 1986;15:759-764 https://doi.org/10.1016/S0300-9785(86)80119-3
  24. Kahn MA: Ameloblastoma in young persons: A clinicopathologic analysis and etiologic investigation. Oral Surg Oral Med Oral Pathol 1989;67:706-715 https://doi.org/10.1016/0030-4220(89)90013-3
  25. Thompson IOC, Ferreira R, van Wyk CW: Recurrent unicystic ameloblastoma of the maxilla. Br J Oral Maxillofac Surg 1993; 31:180-182 https://doi.org/10.1016/0266-4356(93)90121-C
  26. Shatkin S, Hoffmeister FS: Ameloblastoma: a rational approach to therapy. Oral Surg Oral Med Oral Pathol 1965;20:421-435 https://doi.org/10.1016/0030-4220(65)90231-8
  27. Muller H, Slootweg PJ: The ameloblastoma, the controversial approach to therapy. J Maxillofac Surg 1985;12:79-84
  28. Seldin SD: Amelobalastoma in young patient, report of two cases. J Oral Surg 1961;19:508 https://doi.org/10.1016/0030-4220(65)90014-9
  29. Waldron CA: Ameloblastoma in perspective. J Oral Surg 1966; 24:331
  30. Rsaknis PJ, Nelson JF: The maxillary ameloblastoma: an analysis of 24 cases. J Oral Surg 1980;38:336-342