Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Anti-stress effects of Sihoueokgantang in the passive avoidance test and the forced swimming test

시호억간탕(柴胡抑肝湯)이 스트레스로 인한 기억저하와 우울행동에 미치는 영향

  • Jo, Yong-Kook (Dept. of Formulae Pharmacology, College of Oriental Medicine, Kyungwon University) ;
  • Lee, Tae-Hee (Dept. of Formulae Pharmacology, College of Oriental Medicine, Kyungwon University)
  • 조용국 (경원대학교 한의과대학 방제학교실) ;
  • 이태희 (경원대학교 한의과대학 방제학교실)
  • Published : 2007.12.30
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Abstract

Objectives: This study is carried out to investigate the anti-stress effects of the sihoueokgantang in rats. Methods: we performed the passive avoidance test and the forced swimming test. The degrees of TH were also measured with immunohistochemical method in the regions of VTA and LC. Results: 1. As the results of the passive avoidance test. the sihoueokgantang showed tendency to improvement in compared with control group. 2. As the results of the forced swimming test, immobility of rats was significantly decreased in sihoueokgantang in compared with control group. 3. As the results of TH expression in the region of the LC, TH-immunoreactive cells were significantly decreased in the sihoueokgantang 100 mg/kg. As the results of TH expression in the region of the VTA. TH-immunoreactive cells were significantly decreased in the sihoueokgantang 400 mg/kg. Conclusion: As the results above, it can be considered that sihoueokgantang has the effects of preventing depression and memory decrease caused by stress.

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