Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Acute Toxicity Study on Samul-tang(Siwu-tang) in Mice

ICR 마우스를 이용하여 사물탕(四物湯)의 급성 독성에 관한 연구

  • Ma, Jin-Yeul (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Yu, Young-Beob (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Ha, Hye-Kyung (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Huang, Dae-Sun (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Ma, Choong-Je (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Shin, Hyun-Kyoo (Dept. of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
  • 마진열 (한국한의학연구원 한약제제연구부) ;
  • 유영법 (한국한의학연구원 한약제제연구부) ;
  • 하혜경 (한국한의학연구원 한약제제연구부) ;
  • 황대선 (한국한의학연구원 한약제제연구부) ;
  • 마충제 (한국한의학연구원 한약제제연구부) ;
  • 신현규 (한국한의학연구원 한약제제연구부)
  • Published : 2007.12.30
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Abstract

Objectives: Samul-tang(Siwu-tang) has been traditionally prescribed a medicine as a restorative. Methods: In this study, we investigated the acute toxicity about water-extracted Samul-tang(Siwu-tang). Twenty-five mice completed 14 days of oral Samul-tang(Siwu-tang) at the respective doses of 0(control group), 2560, 3200, 4000 and 5000mg/kg. Results: We observed survival rates, general toxicity, change of body weight, and autopsy. Conclusions: Compared with the control group, we could not find any toxic alteration in all treated groups (2560, 3200, 4000 and 5000mg/kg). $LD_{50}$ of Samul-tang(Siwu-tang) was over 5000mg/kg and it is very safe to ICR mice.

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