The Korea Journal of Herbology (대한본초학회지)
- Volume 22 Issue 4
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- Pages.287-300
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- 2007
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
A study on Genotoxicity Test of Hyeong-gae-yeon-gyo-tang extract
형개연교탕(荊芥連翹湯) 추출물의 유전독성(遺傳毒性) 평가
- Jee, Seon-Young (College of Oriental Medicine, Daegu Haany University) ;
- Hwang, Sun-Yi (College of Oriental Medicine, Daegu Haany University) ;
- Lee, Jong-Rok (College of Oriental Medicine, Daegu Haany University) ;
- Kim, Sang-Chan (College of Oriental Medicine, Daegu Haany University)
- Published : 2007.12.31
Abstract
Objectives : The genotoxicity of extract of "Hyeonggaeyeongyotang", a polyherbal formula has been used as a tonic agents in oriental medicine was tested. Methods : Extract of "Hyeonggaeyeongyotang" was tested by In Vitro Chromosome Aberration Test, Bacterial Reverse Mutation Assay and Micronucleus test according to OECD Guidelines and KFDA Guidelines [2005-60]. Results : The obtained results were as follows: 1. Chromosome Aberration Test: No significant changes in the number of aberrant metaphases having structural and number of aberrations were detected in all concentrations of "Hyeonggaeyeongyotang" extracts treated in this study. 2. Bacterial Reverse Mutation Assay: No significant increases in the number of revertant colonies compared to its negative control were detected in all concentrations of "Hyeonggaeyeongyotang" extracts treated in this study against all 5 strains except for
Keywords
- Hyeonggaeyeongyotang;
- Genotoxicity;
- Chromosome Aberration Test;
- Bacterial Reverse Mutation Assay;
- Micronucleus test