The Korea Journal of Herbology (대한본초학회지)
- Volume 22 Issue 4
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- Pages.233-238
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- 2007
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
Effect of Scutellariae Radix on Expression of Cytokines and Chemokines Levels in Human Mast Cells (HMC-1)
황금(黃芩)이 사람 비만세포의 사이토카인 및 케모카인 분비에 미치는 영향
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Leem, Kang-Hyun
(College of Korean Medicine, Semyung University) ;
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Kim, Myung-Gyou
(College of Korean Medicine, Semyung University) ;
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Lee, Se-Na
(College of Korean Medicine, Semyung University) ;
- Kim, Ji-Woo (College of Korean Medicine, Semyung University) ;
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Lee, Pyeong-Jae
(College of Natural Medicine Science, Semyung University)
- Published : 2007.12.31
Abstract
Objectives : Scutellariae Radix (Hwanggeum in Korean) is the root of Scutellaria baicalensis Georgi. Scutellariae Radix is well known to be used as a medicine for common cold, upper respiratory infections, and to strengthen and regulate the immune system and anemia etc. Little is understood about the roles of Scutellariae Radix in the cytokine and chemokine secretion by immune cells. This study was designed to find out the effects of Scutellariae Radix on the cytokine and chemokine secretion in human mast cells (HMC-1). Methods : We treated hwanggeum according to consistency on HMC-1 and measured cytokines and chemokines levels using flow cytometry CBA system. Results : In hwanggeum treated group, the expression of interferon-inducible protein 10 (IP-10), monocyte chemoattractant protein-1 (MCP-1), chemokine (C-X-C motif) ligand 9 (CXCL9, MIG), interleukin 8 (IL-8), interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 10 (IL-10), and interferon