Biomedical Science Letters (대한의생명과학회지)
- Volume 13 Issue 4
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- Pages.313-317
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- 2007
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Effect of Ailanthi Radicis Cortex Extracts on Melanogenesis
- Cho, Young-Ho (Department of Pharmaceutical Engineering, Konyang University)
- 조영호 (건양대학교 제약공학과)
- Published : 2007.12.31
Abstract
Melanogenesis refers to the biosynthesis of melanin pigment in melanocytes. Melanogenesis is controlled by the intra- and extracellular environments. In the present study, to develop a new whitening agent, it was investigated the antioxidant activity and the inhibitory effect of Ailanthi Radicis Cortex extract on tyrosinase activity and on melanogenesis in the B16/F1 melanoma cells. The inhibition ratio of tyrosinase activity of ethylacetate fraction from Ailanthi Radicis Cortex was higher than that of arbutin. The ethylacetate fraction showed scavenging activities of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and superoxide anion radicals in a dose dependent manner. The highest inhibitory activity of melanogenesis was also in ethylacetate fraction (