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The Korean Association of Immunobiologists (대한면역학회)
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The Th17 and Autoimmune Arthritis

Th17과 자가면역 관절염

  • Cho, Mi-La (Rheumatism Research Center (RhRC), The Catholic University of Korea) ;
  • Heo, Yu-Jung (Rheumatism Research Center (RhRC), The Catholic University of Korea) ;
  • Park, Jin-Sil (Rheumatism Research Center (RhRC), The Catholic University of Korea) ;
  • Lee, Seon-Yeong (Rheumatism Research Center (RhRC), The Catholic University of Korea) ;
  • Sung, Young-Chul (Biotech Center, Department of Life Science, Pohang University of Science and Technology) ;
  • Kim, Ho-Youn (Rheumatism Research Center (RhRC), The Catholic University of Korea)
  • 조미라 (가톨릭대학교 의과대학 류마티스연구센터) ;
  • 허유정 (가톨릭대학교 의과대학 류마티스연구센터) ;
  • 박진실 (가톨릭대학교 의과대학 류마티스연구센터) ;
  • 이선영 (가톨릭대학교 의과대학 류마티스연구센터) ;
  • 성영철 (포항공과대학 생명과학과) ;
  • 김호연 (가톨릭대학교 의과대학 류마티스연구센터)
  • Published : 2007.03.30
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Abstract

Autoimmune arthritis, such as rheumatoid arthritis (RA), is a chronic inflammatory disorder that primarily affects the joints and then results in their progressive destruction. Effector Th cells have been classified as Th1 and Th2 subsets based on their cytokine expression profiles and immune regulatory function. Another subset of T cells termed Th17 was recendy discovered and known to selectively produce IL-17. Also, Th17 was shown to be generated by TGF${\beta}$ and IL-6 and maintained by IL-23. IL-17 is a proinflammatory cytokine that is considered to involve the development of various inflammatory autoimmune diseases such as RA, asthma, lupus, and allograft rejection. IL-17 is present in the sera, synovial fluids and synovial biopsies of most RA patient. IL-17 activates RA synovial fibroblasts to synthesize IL-6, IL-8 and VEGF via PI3K/Akt and NF-${\kappa}B$ dependent pathway. IL-17 increases IL-6 production, collagen destruction and collagen synthesis. In addition, it not only causes bone resorption but also increases osteoclastogenesis and fetal cartilage destruction. Inhibition of the IL-17 production may contribute a novel therapeutic approach along with potent anti-inflammatory effect and with less immunosuppressive effect on host defenses.

Keywords

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