IMMUNE NETWORK

  • 제7권2호
  • /
  • Pages.87-94
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  • 2007
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
권호 표지

알레르기 비염 및 부비동염에 의한 아데노이드의 국소 면역에 대한 고찰

Local Immunity of Pediatric Adenoid with Allergic Rhinitis & Sinusitis

  • 여승근 (경희대학교 의과대학 이비인후과학교실) ;
  • 박동춘 (가톨릭대학교 의과대학 산부인과학교실) ;
  • 홍창기 (경희대학교 의과대학 이비인후과학교실) ;
  • 심주섭 (경희대학교 의과대학 이비인후과학교실) ;
  • 차창일 (경희대학교 의과대학 이비인후과학교실)
  • Yeo, Seung-Geun (Department of Otorhinolaryngology, Head & Neck Surgery, College of Medicine, Kyung Hee University) ;
  • Park, Dong-Choon (Department of Obstetric and Gynecology, College of Medicine, The Catholic University of Korea) ;
  • Hong, Chang-Kee (Department of Otorhinolaryngology, Head & Neck Surgery, College of Medicine, Kyung Hee University) ;
  • Sim, Ju-Sup (Department of Otorhinolaryngology, Head & Neck Surgery, College of Medicine, Kyung Hee University) ;
  • Cha, Chang-Il (Department of Otorhinolaryngology, Head & Neck Surgery, College of Medicine, Kyung Hee University)
  • 발행 : 2007.06.30
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초록

Background: Chronic rhino-sinusitis and persistent allergic rhinitis is often cited as risk factor for developing adenoid hypertrophy or adenoiditis, but this relationship has not been studied extensively. In this study, we evaluated the mucosal barrier, squamous changes of ciliated epithelium, IgA secretion and BCL-6 expression in adenoids, and adenoid size. Methods: Six children with allergic rhinitis and sinusitis, nine children with only allergic rhinitis, nine children with only sinusitis and six children without any history of allergic rhinitis and sinusitis were enrolled. H-E stain of adenoid for squamous metaplasia, immunohistochemical study of adenoid for IgA and BCL-6, cytokeratin stain for evaluation of mucosal barrier and lateral view X-ray for adenoid size were performed. ANOVA test was used in the analysis and data showing p value of less than 0.05 were considered significant. Results: The number of ciliated cells had tendency to be decreased and squamous metaplasia had tendency to be increased in three experimental groups (p>0.05). Deterioration of mucosal barrier had tendency to be detected in three experimental groups than control group (p>0.05). BCL-6 had tendency to be increased and IgA secretion had tendency to be decreased in three experimental groups (p>0.05). There is no difference in adenoid size between three experimental groups and control group. Conclusion: Despite the expectation that adenoid would be affectecd by allergic rhinitis and rhino-sinusitis, we found no evidence for influence of adenoid immunity.

키워드

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