Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Intake of dietary phytoestrogen and indices of antioxidant and bone metabolism of pre- and post-menopausal Korean women

  • Jang, Jeong-Hee (Department of Food Science and Nutrition, Catholic University of Daegu) ;
  • Yoon, Ji-Young (Department of Food Science and Nutrition, Catholic University of Daegu) ;
  • Cho, Sung-Hee (Department of Food Science and Nutrition, Catholic University of Daegu)
  • Published : 2007.12.31
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Abstract

A group of 101 women, aged 40-65 years consisted of 48 premenopausal subjects and 53 postmenopausal ones living in Daegu and Gyeongbuk area in Korea were evaluated with their general characteristics, lifestyle factors, nutrient and phytoestrogen intakes, blood and urinary indices concerning antioxidant status and bone metabolism. Body mass index (BMI), waist hip ratio (WHR) and systolic blood pressure (SBP) of the postmenopausal women were significantly higher (23.8, 0.86, and 126.9 mmHg, respectively) than those of the premenopausal women (22.6, 0.82, and 115.9 mmHg; respectively). Nutrient intakes of the postmenopausal and premenopausal groups were not different except lower fat intake and higher dietary fiber and iron intakes in the postmenopausal group. Daily total phytoestrogen intake was significantly higher in the postmenopausal group (48.54 mg) than the premenopausal (31.41 mg) and was resulted mostly from higher intakes of daidzein and genistein from soy and soy products (45.42 mg vs 28.91 mg). Serum genistein level and excretion of enterolactone, major lignan metabolite, were not very different between the two groups. Serum retinal and ${\alpha}$- tocopherol levels were higher in the postmenopausal group but TBARS levels were not different between the two groups. Serum osteocalcin (7.18 ng/mL) and urinary deoxypyridinoline (7.15 nmol/mmol creatinine), in the postmenopausal group were significantly higher than those in the premenopausal group (4.80 ng/mL, 5.95 nmol/mmol creatinine). Urinary excretion of enterolactone was positively correlated with serum osetocalcin in premenopausal women and serum genistein negatively correlated with the urinary DPD in postmenopausal women. Dietary phytoestrogen intake was negatively correlated with serum level of TBARS in all subjects. It is concluded that the effect of total phytoestrogen intake is beneficial on body antioxidant status in all middle-aged women regardless of menopause but the effect on bone metabolism appears different by the type of the phytoestrogen and the menopausal state.

Keywords

References

  1. Adlercreutz H & Mazur W (1997). Phyto-estrogens and western diseases. Ann Med 29:95-120 https://doi.org/10.3109/07853899709113696
  2. Bieri G, Tolliver JJ & Catignani GL (1979). Simultaneous determination of alpha-tocopherol in plasma or red blood cells by high pressure liquid chromatography. Am J Clin Nutr 32:2143-2149 https://doi.org/10.1093/ajcn/32.10.2143
  3. Boccardo F, Lunardi G, Guglielmini P, Parodi M, Murialdo R, Schettini G & Rubagotti A (2004). Serum enterolactone levels and the risk of breast cancer in women with palpable cysts. Eur J Cancer 40:84-89 https://doi.org/10.1016/S0959-8049(03)00576-8
  4. Boker LK, Van der Schouw YT, De Kleijn MJJ, Jacques PF, Grobbee DE & Peteeters PHM (2002). Intake of dietary phytoestrogens by Dutch women. J Nutr 132:1319-1328
  5. Choi MK, Kim MH, Sung CJ, Lee WY & Park JD (2005). A Study on Relation among Habitual Isoflavone Intake, Blood Pressure and Serum Lipid Parameters in Korean Men and Women over 20 Years Old. Korean Journal of Community Nutrition 10:493-500
  6. Choi SH, Lee SY & Kim YJ (2000). The pattern of urinary deoxypyridinoline and serum osteocalcin across menopausal transition in women. Journal of the Korean Academy of Family Medicine 21:1552-1559
  7. Cornwell T, Cohick W & Raskin I (2004). Dietary phytoestrogen and health. Phytochemistry 65:995-1016 https://doi.org/10.1016/j.phytochem.2004.03.005
  8. Cui H-S, Lee D-H & Shin M-K (2006). A study on dialy isoflavone intake from soy foods and urinary excretion of deoxypyridinolile, Ca, Zn in postmenopausal women with ostoporosis. Journal of the East Asian Society of Dietary Life 16:421-428
  9. De Klein MJJ, Van der Schouw YT, Wilson PWF, Adlercreutz H, Mazur W, Grobbee DE & Jacques PF (2001a). Intakes of dietary phytoestrogen is low in postmenopausal women in the United States: The Framingham Study. J Nutr 131:1826-1832
  10. De Klein MJJ, Van der Schouw YT, Wilson PWF, Grobbee DE & Jacques PF (2002b). Dietary phytoestrogen is associated with a favorable metabolic cardiovascular risk profile in postmenopausal women in the United States: The Framingham Study. J Nutr 132:276-282 https://doi.org/10.1093/jn/132.2.276
  11. Haarbo J, Marslew U, Gotfredsen A & Christiansen C (1991). Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause. Metabolism 40:1323-1326 https://doi.org/10.1016/0026-0495(91)90037-W
  12. Horn-Ross PL, Lee M, John EM & Koo J (2000). Sources of phytoestrogen exposure among non-Asian women in California, USA. Cancer Causes Control 11:299-302 https://doi.org/10.1023/A:1008968003575
  13. Hutchins AM, Slavin JL & Lampe JW (1995). Urinary isoflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products. J Am Diet Assoc 95:545-551 https://doi.org/10.1016/S0002-8223(95)00149-2
  14. Hutchins AM, McIver IE & Johnston CS (2005). Soy isoflavone and ascorbic acid supplementation alone or in combination minimally affect plasma lipid peroxides in healthy postmenopausal women. J Am Diet Assoc 105:1134-1347 https://doi.org/10.1016/j.jada.2005.04.028
  15. Kikkinen A, Valsta LM, Virtamo J, Stumpf K, Adlercreutz H & Pietinen P (2003). Intake of lignans is associated with serum enterollactone concentration in Finnish Men and Women. J Nutr 133:1830-1833
  16. Kawana K, Kushida K, Takahashi M, Ohishi T, Denda M, Yamazaki K & Inoue T (1994). The effect of menopause on biochemical markers and ultrasound densitometry in healthy females. Calcif Tissue Int 55:420-425 https://doi.org/10.1007/BF00298555
  17. Kim HW & Khil JM (2007). A study onisoflavone intake from soy foods and perimenstrural symptoms. Journal of Korean Academy of Nursing 37:276-285 https://doi.org/10.4040/jkan.2007.37.3.276
  18. Kim JS & Kwon CS (2001). Estimated dietary isoflavone intake of Korean population based on National Nutrition Survey. Nutr Res 21:947-953 https://doi.org/10.1016/S0271-5317(01)00310-4
  19. Kim MK, Chung BC, Yu VY, Nam JH, Lee HC, Huh KB & Lim SK (2002). Relationship of urinary phyto-osetrogen excretion to BMD in postmenopausal women. Clin Endocrinol 56:321-328 https://doi.org/10.1046/j.1365-2265.2002.01470.x
  20. Kirk P, Patterson RE & Lampe J (1999). Development of a soy food frequency questionnaire to estimate isoflavone consumption in US adults. J Am diet Assoc 99:558-563 https://doi.org/10.1016/S0002-8223(99)00139-X
  21. Korean Dietetic Association (1999) One serving size by picture
  22. Korea National Statistical Office. (2005) Annual Report on the Vital Statistics
  23. Korean Nutrition Society. (2005) Dietary Reference Intakes for Koreans
  24. Lampe JW (2003). Isoflavonoid and lignan phytoestrogens as dietary biomarkers. J Nutr 133:956S-964S
  25. Lee SK, Lee MJ, Yoon S & Kwon DJ (2000). Estimated isoflavone intake from soy products in Korean middle-aged women. Journal of the Korean Society of Food Science and Nutrition 29:948-956
  26. Lin X, Switzer BR & Demark-Wahnefried W (2001). Effect of mammalian lignans on the growth of prostate cancer cell lines. Anticancer Res 21:3995-3999
  27. Maskarine G, Singh S, Meng L & Franke AA (1998). Dietary soy intake and urinary isoflavone excretion among women from a multiethnic population. Cancer Epidemiol Biomakers Prev 7:613-619
  28. Murkies AL, Wilcox G & Davis SR (1998). Clinical review 92; Phytoestrogens. J. Clin. Endocrinol. Metab., 83:297-303 https://doi.org/10.1210/jc.83.2.297
  29. Peichl P, Griesmacher A, Pointinger P, Marteau R, Hartl W, Gruber W & Broll H (1998). Association between female sex hormones and biochemical markers of bone turnover in peri-and postmenopausal womens. Calcif Tissue Int 62:388-394 https://doi.org/10.1007/s002239900450
  30. Reinli K & Block G (1996). Phytoestrogen contents of foods- a compendium of literuatue values. Nutr Cancer 26:123-248 https://doi.org/10.1080/01635589609514470
  31. Saga SF, Ichimura K, Nagai T, Shinoda M & Matsuzaki S (2003). Coumestrol as well as isoflavones in soybean extract prevent bone resorption in ovariectomized rats. Endocr Regul 37:145-152
  32. Tikkanen MJ, Wahala K, Ojala S, Vihma V & Adlercreutz H (1998). Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance. Proc Natl Acad Sci USA, 95: 3106-3110
  33. USDA-IOWA University database (www.nal.usda.gov/fnic/foodcomp)
  34. Valsta LM, Kikkinen A, Mazur W, Nurmi T, Lampi A-M, Ovaskainen M-L, Korhonen T, Adlercreutz H & Pietinen P (2003). Phyto-estorogen database of foods and average intake in Finland. Brit J Nutr 89:S31-S38
  35. Ward WE, Ynan YV, Cheung AM & Thompson LU (2001). Exposure to flaxseed and its purified lignan reduces bone strength in young but not older male rats. J Toxicol and Environ Healt 63:53-65 https://doi.org/10.1080/152873901750128362
  36. Whitten PL, Patisaul HB & Young LJ (2002). Neurobehavioral actions of coumestrol and ralated isoflavonoids in rodents. Neurotoxicol Teratol 24:47-54 https://doi.org/10.1016/S0892-0362(01)00192-1
  37. Wing RR, Mattews KA, Kuller LH, Meilahn EN & Plantinga PL (1991). Weight gain at the time of menopause. Arch Intern Med 151:97-102 https://doi.org/10.1001/archinte.151.1.97
  38. Writing group for the WHI investigators (2002). Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the womesn's health initiative randomized controlled trial. JAMA 288:321-333 https://doi.org/10.1001/jama.288.3.321
  39. Yagi K (1976). A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 15:212-216 https://doi.org/10.1016/0006-2944(76)90049-1
  40. Zava DT & Duwe G. (1997) Estrogenic and antiestrogenic properties of genistein and other flavonoids in human breast cancer cell in vitro. Nutr. Cancer, 27: 31-40 https://doi.org/10.1080/01635589709514498