Synthesis of 6-(Thienylmethylene)penam Sulfones and their ${\beta}$-Lactamase Inhibitory Activities

6-(티에닐메칠렌)페남 설폰의 합성과 ${\beta}$-Lactamase 저해활성

  • Published : 2007.12.31

Abstract

The resistance of bacteria against ${\beta}$-lactam antibiotics is mainly caused by the production of ${\beta}$-lactamase enzymes. ${\beta}$-Lactamase inhibitors are used in combination with known antibiotics to overcome the growing problem of bacterial resistance. We prepared 6-(thienylmethylene)penam sulfones for the development of potent ${\beta}$-lactamase inhibitors and evaluated their ${\beta}$-lactamase inhibitory activities.

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References

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