Primary Cerebellar Hodgkin's Lymphoma

  • Hwang, Chul-Yoon (Department of Neurosurgery, Brain Tumor Institute College of Medicine Dong-A University) ;
  • Song, Young-Jin (Department of Neurosurgery, Brain Tumor Institute College of Medicine Dong-A University) ;
  • Kim, Dae-Chul (Department of Pathology, Brain Tumor Institute College of Medicine Dong-A University) ;
  • Choi, Sun-Seob (Department of Diagnostic Radiology, Brain Tumor Institute College of Medicine Dong-A University) ;
  • Choi, Young-Min (Department of Onco-radiology, Brain Tumor Institute College of Medicine Dong-A University) ;
  • Kim, Ki-Uk (Department of Neurosurgery, Brain Tumor Institute College of Medicine Dong-A University)
  • 발행 : 2007.08.30

초록

Authors report a very rare case of primary Hodgkin's lymphoma limited to the cerebellum. A 64-year-old female patient presented with headache, nausea, and vomiting. Magnetic resonance imaging of the brain revealed a nodular enhancing mass in the left cerebellar hemisphere. Tumor was removed totally with retromastoid suboccipital approach. Diagnosis was Hodgkin's lymphoma of mixed cellularity type, consisting of a dense mixed inflammatory infiltrate containing scattered large atypical mononuclear Hodgkin's cell and multinucleated Reed-Sternberg cells. Systemic work-up for the Hodgkin's lymphoma was followed with negative result. Postoperative radiation therapy was given and the patient is disease-free at 16 months after the operation.

키워드

참고문헌

  1. Akyuz C, Yalcin B, Atahan IL, Varan A, Kutluk MT, Buyukpamukcu M : Intracranial involvement in Hodgkin's disease. Pediatr Hematol Oncol 22 : 589-596, 2005 https://doi.org/10.1080/08880010500198863
  2. Antonio G, Dahlstrom J, Chandran KN, O'Neil R : Cerebellopontine angle Hodgkin's disease : case report. Australas Radiol 44 : 115-117, 2000 https://doi.org/10.1046/j.1440-1673.2000.00755.x
  3. Ashby MA, Barber PC, Holmes AE, Freer CE, Collins RD : Primary intracranial Hodgkin's disease : a case report and discussion. Am J Surg Pathol 12 : 294-299, 1988 https://doi.org/10.1097/00000478-198804000-00006
  4. Bender BL, Mayernik DG : Hodgkin's disease presenting with isolated craniospinal involvement. Cancer 15 : 1745-1748, 1986
  5. Biagi J, MacKenzie RG, Lim MS, Sapp M, Berinstein N : Primary Hodgkin's disease of the CNS in an immunocompetent patient : a case study and review of the literature. Neuro-oncol 2 : 239-243, 2000 https://doi.org/10.1215/15228517-2-4-239
  6. Cavalli F : Rare syndromes in Hodgkin's disease : review. Ann Oncol 9(Suppl 5) : 109-113, 1998
  7. Citow JS, Rini B, Wollmann R, Macdonald RL : Isolated, primary extranodal Hodgkin's disease of the spine : case report. Neurosurgery 49 : 453-457, 2001 https://doi.org/10.1097/00006123-200108000-00037
  8. Clark WC, Callihan T, Schwartzberg L, Fontanesi J : Primary intracranial Hodgkin's lymphoma without dural attachment : case report. J Neurosurg 76 : 692-695, 1992 https://doi.org/10.3171/jns.1992.76.4.0692
  9. Deckert-Schluter M, Marek J, Setlik M, Markova J, Pakos E, Fischer R, et al : Primary manifestation of Hodgkin's disease in the central nervous system. Virchows Arch 432 : 477-481, 1998 https://doi.org/10.1007/s004280050195
  10. Doorly TP, Farrell MA, Phillips J : Primary intracerebral Hodgkin's lymphoma. J Neurol Neurosurg Psychiatry 50 : 1048-1050, 1987 https://doi.org/10.1136/jnnp.50.8.1048
  11. Johnson MD, Kinney MC, Scheithauer BW, Briley RJ, Hamilton K, McPherson WF, et al : Primary intracerebral Hodgkin's disease mimicking meningioma : case report. Neurosurgery 47 : 454-457, 2000 https://doi.org/10.1097/00006123-200008000-00038
  12. Klein R, Mullges W, Bendszus M, Woydt M, Kreipe H, Roggendorf W : Primary intracerebral Hodgkin's disease : report of a case with Epstein-Barr virus association and review of the literature. Am J Surg Pathol 23 : 477-481, 1999 https://doi.org/10.1097/00000478-199904000-00014
  13. Laperriere NJ, Cerezo L, Milosevic MF, Wong CS, Patterson B, Panzarella T : Primary lymphoma of brain : results of management of a modern cohort with radiation therapy. Radiother Oncol 43 : 247-252, 1997 https://doi.org/10.1016/S0167-8140(97)00074-1
  14. Maggioni F, Zanchin F, Vecchio F, Giordano R, De Zanche L : Paraneoplastic syndrome in the course of Hodgkin disease : Case report. Ital J Neurol Sci 10 : 207-210, 1989 https://doi.org/10.1007/BF02333621
  15. Morawa E, Ragam A, Sirota R, Nabhan C : Hodgkin's lymphoma involving the CNS. J Clin Oncol 25 : 1437-1438, 2007 https://doi.org/10.1200/JCO.2006.10.1691
  16. Muzaffar S, Siddiqui MS, Siddiqui I, Soomro IN, Pervez S, Kayani N, et al : Central nervous system lymphomas : a histologic and immunophenotypic analysis. J Pak Med Assoc 50 : 141-144, 2000
  17. Nagashima K, Mori S, Yoshimasu N, Takahashi K : Primary Hodgkin's disease of the falx cerebri. Acta Neuropathol 51 : 161-163, 1980 https://doi.org/10.1007/BF00690459
  18. Pallesen G, Hamilton-Dutoit SJ, Rowe M, Young LS : Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease. Lancet 337 : 320-322, 1991 https://doi.org/10.1016/0140-6736(91)90943-J
  19. Sapozink MD, Kaplan HS : Intracranial Hodgkin's disease. A report of 12 cases and review of the literature. Cancer 52 : 1301-1307, 1983 https://doi.org/10.1002/1097-0142(19831001)52:7<1301::AID-CNCR2820520728>3.0.CO;2-5
  20. Schricker JL, Smith DE : Primary intracerebral Hodgkin's disease. Cancer 8 : 629-633, 1955 https://doi.org/10.1002/1097-0142(1955)8:3<629::AID-CNCR2820080329>3.0.CO;2-T
  21. Shet AS, Saba N, Rausch D, Belzer M : Intra-cranial lesions in a patient with Hodgkin lymphoma. Leuk Lymphoma 45 : 419-422, 2004 https://doi.org/10.1080/1042819031000139602
  22. Sickler GK, Hanson SK, Hsu SM, Papasozomenos SC : Primary intracerebral Hodgkin's disease : a case report. Clin Neuropathol 9 : 143-147, 1990
  23. Sparling HJ, Adams RD : Primary Hodgkin's sarcoma of the brain. Arch Pathol 42 : 338-344, 1946