Journal of Korean Neurosurgical Society

  • 제41권6호
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  • Pages.397-402
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  • 2007
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  • 2005-3711(pISSN)
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  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
권호 표지

Epileptogenic Properties of Balloon Cells in Cortical Tubers of Tuberous Sclerosis : Upregulation of Drug Resistance Proteins

  • Kang, Nam-Gu (Department of Neurosurgery, Gwangju Christian Hospital) ;
  • Chang, Hong-Joen (Department of Neurosurgery, Gwangju Christian Hospital) ;
  • Ok, Young-Cheol (Department of Neurosurgery, Gwangju Christian Hospital) ;
  • Lee, Rae-Seop (Department of Neurosurgery, Gwangju Christian Hospital) ;
  • Park, Seung-Kyu (Department of Neurosurgery, Gwangju Christian Hospital) ;
  • Lim, Jun-Seob (Department of Neurosurgery, Gwangju Christian Hospital) ;
  • Cho, Kyu-Yong (Department of Neurosurgery, Gwangju Christian Hospital) ;
  • Kim, Hyung-Ihl (Department of Neurosurgery, Jeonju Presbyterian Hospital) ;
  • Kim, Jae-Hyoo (Departments of Neurosurgery, Chonnam National University Medical School) ;
  • Oh, Hyun-Sik (Departments of Pathology, Chonnam National University Medical School) ;
  • Lee, Min-Cheol (Departments of Pathology, Chonnam National University Medical School)
  • 발행 : 2007.06.30
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초록

Objective : Balloon cells and dysplastic neurons are histopathological hallmarks of the cortical tubers of tuberous sclerosis complex [TSC] and focal cortical dysplasia [FCD] of the Taylor type. They are believed to be the epileptogenic substrate and cause therapeutic drug resistant epilepsy in man. P-glycoprotein [P-gp] is the product of multidrug resistance gene [MDR1], and it maintains intracellular drug concentration at a relatively low level. The authors investigated expression of P-gp in balloon cells and dysplastic neurons of cortical tubers in patients with TSC. Methods : An immunohistochemical study using the primary antibody for P-gp, as an indicative of drug resistance, was performed in the cortical tuber tissues in two patients of surgical resection for epilepsy and six autopsy cases. Results : Balloon cells of each lesion showed different intensity and number in P-gp immunopositivity. P-gp immunopositivity in balloon cells were 28.2%, and dysplastic neurons were 22.7%. These immunoreactivities were more prominent in balloon cells distributed in the subpial region than deeper region of the cortical tubers. Capillary endothelial cells within the cortical tubers also showed P-gp immunopositivity. Conclusion : In this study, the drug resistance protein P-glycoprotein in balloon cells and dysplastic neurons might explain medically refractory epilepsy in TSC.

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참고문헌

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