Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Synthesis of 2'-Hydroxydihydrochalcone from Flavone

  • Kim, Mi-Hyang (Metalloenzyme Research Group and Department of Biotechnology, Chung-Ang University) ;
  • Shin, Bok-Kyu (Metalloenzyme Research Group and Department of Biotechnology, Chung-Ang University) ;
  • Won, Dong-Ho (Metalloenzyme Research Group and Department of Biotechnology, Chung-Ang University) ;
  • Han, Jae-Hong (Metalloenzyme Research Group and Department of Biotechnology, Chung-Ang University)
  • Published : 2007.06.30
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Abstract

To establish the synthetic method for dihydrochalcones as an important bioactive compounds, 2'-hydroxydihydrochalcone has been synthesized from the reduction of flavone in 20% yield. Flavone with five equivalents of ammonium formate in the presence of Pd/C in methanol under $N_2$ atmosphere produced the C-ring opened product. It was characterized by UV-VIS, ESI-MS and $^1H-NMR$ spectroscopy, and identified as 2'-hydroxydihydrochalcone.

Keywords

References

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