Journal of the Optical Society of Korea

  • 제11권4호
  • /
  • Pages.162-172
  • /
  • 2007
  • /
  • 1226-4776(pISSN)
  • /
  • 2093-6885(eISSN)
한국광학회 (Optical Society of Korea)
권호 표지
DOI QR코드

DOI QR Code

Maximizing the Workspace of Optical Tweezers

  • Hwang, Sun-Uk (Department of Mechatronics, Gwangju Institute of Science and Technology(GIST)) ;
  • Lee, Yong-Gu (Department of Mechatronics, Gwangju Institute of Science and Technology(GIST))
  • 투고 : 2007.10.30
  • 발행 : 2007.12.25
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Scanning Laser Optical Tweezers(SLOT) is an optical instrument frequently employed on a microscope with laser being delivered through its various ports. In most SLOT systems, a mechanical tilt stage with a mirror on top is used to dynamically move the laser focal point in two-dimensions. The focal point acts as a tweezing spot, trapping nearby microscopic objects. By adding a mechanical translational stage with a lens, SLOT can be expanded to work in three-dimensions. When two mechanical stages operate together, the focal point can address a closed three-dimensional volume that we call a workspace. It would be advantageous to have a large workspace since it means one can trap and work on multiple objects without interruptions, such as translating the microscope stage. However, previous studies have paid less consideration of the volumetric size of the workspace. In this paper, we propose a new method for designing a SLOT such that its workspace is maximized through optimization. The proposed method utilizes a matrix based ray tracing method and genetic algorithm(GA). To demonstrate the performance of the proposed method, experimental results are shown.

키워드

참고문헌

  1. A. Ashkin, J. M. Dziedzic, and T. Yamane, 'Optical trapping and manipulation of single cells using infraredlaser beams,' Nature, vol. 330, no. 6150, pp. 769-771, 1987 https://doi.org/10.1038/330769a0
  2. D. G. Grier, 'A revolution in optical manipulation,' Nature, vol. 424, no. 6950, pp. 810-816, 2003 https://doi.org/10.1038/nature01935
  3. K. Dholakia and P. Reece, 'Optical micromanipulation takes hold,' Nanotoday, vol. 1, no. 1, pp. 18-27, 2006 https://doi.org/10.1016/S1748-0132(06)70019-6
  4. K. C. Neuman and S. M. Block,'Optical trapping,' Review of Scientific Instruments, vol. 75, no. 9, pp. 2787-2810, 2004 https://doi.org/10.1063/1.1785844
  5. B. A. Brown and P. R. Brown, 'Optical tweezers: Theory and current applications,' American Laboratory, vol. 33, no. 22, pp. 13-20, 2001
  6. A. Ashkin, 'Forces of a single-beam gradient laser trap on a dielectric sphere in the ray optics regime,' Biophysics Journal, vol. 61, no. 2, pp. 569-582, 1992 https://doi.org/10.1016/S0006-3495(92)81860-X
  7. V. Emiliani, D. Sanvitto, M. Zahid, F. Gerbal, and M. Coppey-Moisan, 'Multi force optical tweezers to generate gradients of forces,' Optics Express, vol. 12, no. 17, pp. 3906-3910, 2004 https://doi.org/10.1364/OPEX.12.003906
  8. E. Fallman and O. Axner, 'Design for fully steerable dual-trap optical tweezers,' Applied Optics, vol. 36, no. 10, pp. 2107-2113, 1997 https://doi.org/10.1364/AO.36.002107
  9. C. Mio, T. Gong, A. Terray, and D. W. M. Marr, 'Design of a scanning laser optical trap for multiparticle manipulation,' Review of Scientific Instruments, vol. 71, no. 5, pp. 2196-2200, 2000 https://doi.org/10.1063/1.1150605
  10. S. U. Hwang and Y. G. Lee, 'Topology optimization of optical tweezers setup,' Proc. of SPIE, vol. 5650, pp. 408-417, Dec. 2004 https://doi.org/10.1117/12.582260
  11. I. Y. Park, S. U. Hwang, J. H. Song, and Y. G. Lee, 'Grasping microscopic objects by an optical trapping system controlled by five finger tips,' Proc. of SPIE, vol. 5930, pp. 59301Z-1, Aug. 2005 https://doi.org/10.1117/12.616379
  12. A. H. Forster, M. M. Wang, W. F. Butler, M. Chachisvilis, T. D. Y. Chung, S. C. Esener, J. M. Hall, O. Kibar, K. Lykstad, P. J. Marchand, E. M. Mercer, L. M. Pestana, S. Sur, E. Tu, R. Yang, H. Zhang, and I. Kariv, 'Use of moving optical gradient fields for analysis of apoptotic cellular responses in a chronic myeloid leukemia cell model,' Analytical Biochemistry, vol. 327, no. 1, pp. 14-22, 2004 https://doi.org/10.1016/j.ab.2003.12.017
  13. M. M. Wang, C. A. Schnable, M. Chachisvilis, R. Yang, M. J. Paliotti, L. A. Simons, L. McMullin, N. Hagen, K. Lykstad, E. Tu, L. M. Pestana, S. Sur, H. Zhang, W. F. Butler, I. Kariv, and P. J. Marchand, 'Optical forces for noninvasive cellular analysis,' Applied Optics, vol. 42, no. 28, pp. 5765-5773, 2004 https://doi.org/10.1364/AO.42.005765
  14. S. U. Hwang, I. Y. Park, J. H. Song, T. W. LeBrun, N. G. Dagalakis, C. Gagnon, A. Balijepalli, and Y. G. Lee, 'Three-dimensional scanning optical tweezers,' Proc. of SPIE, vol. 6048, pp. 604803, Dec. 2005 https://doi.org/10.1117/12.644463
  15. I. Ono, S. Kobayashi, and K. Yoshida, 'Global and multi-objective optimization for lens design by realcoded genetic algorithms,' Proc. of SPIE, vol. 3482, pp. 110-121, Sep. 1998 https://doi.org/10.1117/12.321995
  16. J. Beaulieu, C. Gagne, and M. Parizeau, 'Lens system design and re-engineering with evolutionary algorithms,' Proc. of the Genetic and Evolutionary Computing Conference, pp. 155-162, 2002
  17. Y. Purushottam, R. V. H. Prasad, and V. C. Misra, 'Design of ultra-wide band multilayer slant linear polarizer using a genetic algorithm,' Microwave and Optical Technology Letters, vol. 30, no. 2, pp. 119-112, 2001 https://doi.org/10.1002/mop.1237
  18. E. Kerrinckx, L. Bigot, M. Douay, and Y. Quiquempois, 'Photonic crystal fiber design by means of a genetic algorithm,' Optics Express, vol. 12, no. 9, pp. 1990- 1995, 2004 https://doi.org/10.1364/OPEX.12.001990
  19. D. Cojoc, E. D. Fabrizio, L. Businaro, S. Cabrinic, F. Romanatoa, and L. Vaccaria, 'Design and fabrication of diffractive optical elements for optical tweezers arrays by means of e-beam lithography,' Microelectronic Engineering, vol. 61-62, pp. 963-969, 2004 https://doi.org/10.1016/S0167-9317(02)00426-4
  20. M. Gen and R. Cheng, Genetic Algorithms and Engineering Design (John Wiley & Sons, New Jersey, USA, 1997)
  21. F. L. Pedrotti and S. J. L. S. Pedrotti, Introduction to Optics, (Prentice Hall, New Jersey, USA, 1993) Chapter 4

피인용 문헌

  1. Simulation of an oil immersion objective lens: a simplified ray-optics model considering Abbe’s sine condition vol.16, pp.26, 2008, https://doi.org/10.1364/OE.16.021170