Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Combined Effects of the Essential Oil from Pelargonium graveolens with Antibiotics against Streptococcus pneumoniae

  • Choi, Sung-Hee (College of Pharmacy, Duksung Women's University) ;
  • Lim, Sook (College of Pharmacy, Duksung Women's University) ;
  • Shin, Seung-Won (College of Pharmacy, Duksung Women's University)
  • Published : 2007.12.31
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Abstract

The antimicrobial activity of the essential oil from Pelargonium graveolens and its effects when it was combined with current antibiotics against antibiotic-resistant strains of Streptococcus pneumoniae were evaluated. The minimal inhibitory concentrations (MICs) of the essential oil fraction and the main components of this plant were determined for two antibiotic-susceptible and two antibiotic-resistant strains of S. pneumoniae using broth microdilution tests. The combined effects of the oil with erythromycin, norfloxacin, or oxacillin were evaluated using a checkerboard microtitre assay. The combination of the oil fraction of P. graveolens, or its main component, together with the antibiotics tested significantly lowered the MICs of the antibiotics against all of the tested strains with fraction inhibiting concentration indices (FICs) ranging from 0.16 to 1.50. In particular, the activity of norfloxacin against all of the tested strains of S. pneumoniae was enhanced significantly by combination with citronellol. In conclusion, the combination of P. graveolens oil with antibiotics could be used to reduce the effective dose of antibiotic and to modulate the resistance of S. pneumoniae strains.

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