Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Anti-Inflammatory, Analgesic and Hepatoprotective Effect of Semen of Rumex crispus

소리쟁이 종자의 소염진통작용 및 간보호 효과

  • Published : 2007.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Roots of Rumex crispus (Rc) (Polygonaceae) has been used as therapeutic agents of acute and chronic cutaneous diseases, cathartics, fever and jaundice in folk medicines. Recently, Seeds of Rc has known as a digestive, an anticancer agent and a remedy of acute hepatitis, among many traditional folk medicines. So far it isn't reported about pharmacological effects of Rumecis Semen. The present study describes the preliminary evaluations of biological activities, anti-inflammatory activity (AA, Carrageenan) analgesic activity (writhing test), and hepatoprotective activities ($CCl_4$), of its methanol extract, ethyl acetate fraction and butanol fraction. Among them butanol fraction showed the highest activity in analgesic acivity.

Keywords

References

  1. 이창복 (1982) 대한식물도감 향문사 서울 298
  2. 한국약용식물학 연구회 (2001) 종합약용식물학 학창사 서울 153
  3. 배기환 (2001) 한국의 약용식물학 교학사 서울 92
  4. Shanghai Science and Technological Publisher(1985), 'The Dictionary of Chinese Drugs' Vol. 1 Shougakukan, Tokyo, p. 452
  5. Gunaydin K, Topcu G, Ion RM (2002) 1,5-dihydroxyanthraquinones and an anthrone from roots of Rumex crispus. Nat Prod Lett. 16: 65-70 https://doi.org/10.1080/1057563029001/4872
  6. Kim JC, Choi GJ, Lee SW, Kim JS, Chung KY, Cho KY. (2004) Screening extracts of Achyranthes japonica and Rumex crispus for activity against various plant pathogenic fungi and control of powdery mildew. Pest Manag Sci. 60: 803-808 https://doi.org/10.1002/ps.811
  7. Yildirim A, Mavi A, Kara AA (2001) Determination of antioxidant and antimicrobial activities of Rumex crispus L. extracts. J Agric Food Chem. 49: 83-89
  8. Hanan EB, Spindler JW (1968) Lectins in extracts of certain Polygonaceae seed precipitate animal and human serums. Science. 160: 1462-1463 https://doi.org/10.1126/science.160.3835.1462
  9. Young, J. M., Spires, D.A., Bedord, C. J., Wagner, B., De Ballaron, S. J., Young, L. M. (1984) The mouse ear inflammatory response to topical arachidonic acid. J. Invest. Dermatol., 82: 367-371 https://doi.org/10.1111/1523-1747.ep12260709
  10. Rao, T. S., Currie, J. L., Shaffer, A. F., Isakson, P. C. (1993) Comparative evaluation of arachidonic acid(AA) and Tetradecanoyl phorbol acetate(TPA)-induced dermal inflammation. Inflammation, 17: 723-741 https://doi.org/10.1007/BF00920477
  11. Winter, C. A., Risley E. A., Nuss, G. W.(1962) Carrageenininduced edema in hind paw of the rat as an assay for antiinflammatory drugs. Proc. Soc. Exp. Biol., 111: 544-547
  12. Whittle B.A. (1964) The use of changes in capillary permeability to distinguish between narcotic and analgesic. Brith.J. Phamacol. 22: 246-253
  13. Mclean A.E. (1967) The effect of diet and vitamin E on liver injury due to carbon tetrachloride. Br. J. Exp. Pathol. 48: 632-636
  14. Di Rosa, M. D., Giroud, J. P., Willoughby, D. A. (1971) Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J. Pathol., 104: 15-29 https://doi.org/10.1002/path.1711040103
  15. Gilligan, J. P., Lovato, S. J., Erior, M. D. and Jeng, A. Y. (1994) Modulation of carrageenan-induced hind paw edema by substance P. Inflammation, 18: 285-292 https://doi.org/10.1007/BF01534269
  16. Bileviciute, I., Lundeberg, T., Ekblom, A., Theodorsson, E. (1993) Bilateral changes of substance P-, neurokinin A-, calcitonin gene-related peptide- and neuropeptide Y-like immunoreactivity in rat knee joint synovial fluid during acute monoarthritis. Neurosci. Lett., 153: 37-40 https://doi.org/10.1016/0304-3940(93)90071-R
  17. Bonta, I. L., Bult, H., Pamham, M. J. (1977) The presence of prostaglandin-like material in carrageenan-induced rat hind paw inflammation. Br. J. Pharmacol., 60: 290
  18. Blackham, A. Norris, A. A., Woods, F. A. M. (1985) Models for evalating the antiinflammatory effects of inhibitors of arachidonic acid metabolism. J. Pharm. Pharmacol., 37: 787-793 https://doi.org/10.1111/j.2042-7158.1985.tb04969.x
  19. Lo, T. N., Saul, W. F., Lau, S. S.(1987) Carrageenan-stimulated release of arachidonic acid and of lactate dehydrogenase from rat pleural cells. Biochem. Pharmacol., 36: 2405-2413 https://doi.org/10.1016/0006-2952(87)90610-1
  20. Smith, S. R., Watnick, A. W., Bryant, R. W., Billah, M., Siegel, M. I. (1992) Actions of a 5-lipoxygenase inhibitor, Sch 40120, on acute inflammatory responses. J. Pharm. Exp. Ther., 262: 721-728
  21. Zhang, B. H, Gong, D. Z, Mei, M. H. (1999) Protection of regenerating liver after partial hepatectomy from carbon tetrachloride hepatotoxicity in rat. Role of hepatic stimulator substance. J. Gasgroenterol. Hepato., 14: 1010-1017 https://doi.org/10.1046/j.1440-1746.1999.01992.x
  22. Plaa, G. L, and Hewitt, W. R., (1989) Detection and evaluation of chemically induced liver injury. in, Principles and Methods of Toxicology, ed. by A. W. Hayes, pp. 599-628. Raven Press, New York