The Variation of Residual Sulfur Dioxide and Marker Components of Herbal Medicines during Drying Process

건조방법에 따른 한약재 중 이산화황 잔류량 및 지표성분 변화

  • Oh, Chang-Hwan (Department of Oriental Medical Food and Nutrition, Semyung University) ;
  • Seo, Dong-Won (Korea Food Research Institute) ;
  • Yook, Chang-Soo (College of Pharmacy, Kyung Hee University) ;
  • Lee, Young-Jong (College of Oriental Medicine, Kyungwon University) ;
  • Chang, Seung-Yeup (Department of Herbal medicine Evaluation, Korea Food and Drug Administration) ;
  • Ze, Keum-Ryon (Department of Herbal medicine Evaluation, Korea Food and Drug Administration) ;
  • Park, Ju-Young (Department of Herbal medicine Evaluation, Korea Food and Drug Administration) ;
  • Lee, Jong-Pill (Department of Herbal medicine Evaluation, Korea Food and Drug Administration) ;
  • Seong, Rack-Seon (Department of Herbal medicine Evaluation, Korea Food and Drug Administration) ;
  • Park, Ji-Yong (Department of Biotechnology, Yonsei University) ;
  • Ko, Sung-Kwon (Department of Oriental Medical Food and Nutrition, Semyung University) ;
  • Lee, Pyeong-Jae (Department of Natural Medicine Resources, Semyung University)
  • 오창환 (세명대학교 한방식품영양학부) ;
  • 서동원 (한국식품연구원) ;
  • 육창수 (경희대학교 약학대학 한약학과) ;
  • 이영종 (경원대학교 한의과대학) ;
  • 장승엽 (식품의약품안전청 생약평가부) ;
  • 제금련 (식품의약품안전청 생약평가부) ;
  • 박주영 (식품의약품안전청 생약평가부) ;
  • 이종필 (식품의약품안전청 생약평가부) ;
  • 성락선 (식품의약품안전청 생약평가부) ;
  • 박지용 (연세대학교 생명공학과) ;
  • 고성권 (세명대학교 한방식품영양학부) ;
  • 이평재 (세명대학교 자연약재과학과)
  • Published : 2007.12.31

Abstract

The residual sulfur dioxide in the five herbal medicines dried with burning bituminous coal for 9 hours showed from 339 (Glycyrrhizae Radix) to 1,138 mg/kg (Zingiberis Rhizoma) measured right after drying. The residual sulfur dioxide, from 70.1 to 95.5%, was remained in the above five matrices even after 30 days passed. The marker components concentration in above five herbal medicines like glycyrrhizic acid, betaine et al., were almost same after drying in oven and with burning bituminous coal.

Keywords

References

  1. Chang, S.Y., Seong, R.S., Kang, S.J., Lee, J.P., Shin, J.H., Park, J.Y., Jung, Y.J., Kim, J.H., Byun, S.H., Ha, K.W., Park, S.J. and Kim, N.J. (1999) Studies on processing methods for herbal drugs(1). The Annual Report of KFDA. 3: 287-294
  2. KFDA. (2005) Specification and test method for residual sulfur dioxide in herbal medicines
  3. Kim, C.M., Song, B.J. and Na, H.S. (2000) Determination of sulfite contents in medicinal herbs. J. Korean Soc. Food Sci. Nutr. 29(3): 375-379
  4. Kang, K.J., Oh, G.S., Kim, H.I., Choi, Y.H., Kim, Y.J. and Chung, Y.C. (2001) Naturally occurring of sulfur dioxide in medicinal herbs (crude drug materials) and its origin. Korean J. Food Sci. Technol. 33(5): 514-520
  5. Sullivan, D.M. and Smith, R.L. (1985) Determination of sulfite in foods by ion chromatography. Food Technol. 39(7): 45-53
  6. FDA. (1983) Code of Federal Regulations. Washington D.C. Title 21. sec.182
  7. KFDA (2002) Korea Food Code. 1054-1055
  8. Tailor, S.L., Higley, N.A and Buch, R.K. (1986) Sulfite in food. Adv. Food Res. 30: 1-76 https://doi.org/10.1016/S0065-2628(08)60347-X
  9. FAO/WHO. (1979) Guide to the Safe Use of Food Additives. 2nd series
  10. KFDA. (2007) Proposed amendment the 'Specification and test method for residual sulfur dioxide in herbal medicines'. The KFDA advance notice No.2007-190
  11. Lee, M.S., Hwang, I.S., Lee, C.S., Choi, B.H. and Kim, M.H. (2000) Determination of sulfites in crude drugs. The Report of Seoul Metropolitan Government Research Institute of Public Health and Environment. 36: 56-62
  12. Shin T.H. (1999) A study on the sulfites contents in crude drugs. The Report of Chungcheongbuk-do Institute of Health and Environment. 8: 51-57
  13. KFDA. (2002) Korea Food Code, Separate volume. 506-507
  14. KFDA. (2002) The Korean Pharmacopoeia. Eighth Edition
  15. AOAC (1995) Official Methods of Analysis. 16th ed. sec. 990.28. AOAC International, Gaithersbrug, MD, USA
  16. Choi, O.K., Kim, Y.S., Kim, J.H., Kim, B.H. and Kim, M.G. (1999) Determination of total sulfite in crude drugs by Monier- Williams method and automatic distillation. The Report of Kyonggi-do Institute of Health and Environment. 12: 17-24
  17. Lee, J.T. (2006) Research on intake of chinese medicine by Korean KFDA Project Report 102-105