Strengthening Causal Inference in Studies using Non-experimental Data: An Application of Propensity Score and Instrumental Variable Methods

비실험자료를 이용한 연구에서 인과적 추론의 강화: 성향점수와 도구변수 방법의 적용

  • Kim, Myoung-Hee (Department of Preventive Medicine, Eulji University College of Medicine) ;
  • Do, Young-Kyung (Department of Health Policy and Administration, University of North Carolina at Chapel Hill School of Public Health)
  • 김명희 (을지의과대학교 예방의학교실) ;
  • 도영경 (노스캐롤라이나대 보건대학원 보건정책관리학과)
  • Published : 2007.11.30

Abstract

Objectives : This study attempts to show how studies using non-experimental data can strengthen causal inferences by applying propensity score and instrumental variable methods based on the counterfactual framework. For illustrative purposes, we examine the effect of having private health insurance on the probability of experiencing at least one hospital admission in the previous year. Methods : Using data from the 4th wave of the Korea Labor and Income Panel Study, we compared the results obtained using propensity score and instrumental variable methods with those from conventional logistic and linear regression models, respectively. Results : While conventional multiple regression analyses fail to identify the effect, the results estimated using propensity score and instrumental variable methods suggest that having private health insurance has positive and statistically significant effects on hospital admission. Conclusions : This study demonstrates that propensity score and instrumental variable methods provide potentially useful alternatives to conventional regression approaches in making causal inferences using non-experimental data.

Keywords

References

  1. Newhouse JP, McClellan M. Econometrics in outcomes research: The use of instrumental variables. Annu Rev Pub Health 1998; 19: 17-34 https://doi.org/10.1146/annurev.publhealth.19.1.17
  2. Kaufman JS, Kaufman S, Poole C. Causal inference from randomized trials in social epidemiology. Soc Sci Med 2003; 57(12): 2397-2409 https://doi.org/10.1016/S0277-9536(03)00135-7
  3. Kaufman JS, Cooper RS. Seeking causal explanations in social epidemiology Am J Epidemiol 1999; 150(2): 113-120 https://doi.org/10.1093/oxfordjournals.aje.a009969
  4. Jary D, Jary J. HarperCollins Dictionary of Sociology. New York: HarperCollins Publishers, Ltd.; 1991
  5. Lewis D. Causation. J Philos 1973; 70(17): 556-567 https://doi.org/10.2307/2025310
  6. Maldonado G, Greenland S. Estimating causal effects. Int J Epidemiol 2002; 31(2): 422-429 https://doi.org/10.1093/ije/31.2.422
  7. Oakes JM, Johnson PJ. Propensity score matching for social epidemiology. In: Oakes JM, Kaufman JS, editors. Methods for Social Epidemiology. San Francisco: Jossey-Bass; 2006. p. 370-392
  8. McClellan M, McNeil BJ, Newhouse JP. Does more intensive treatment of acute myocardial infarction in the elderly reduce mortality? Analysis using instrumental variables. JAMA 1994; 272(11): 859-866 https://doi.org/10.1001/jama.272.11.859
  9. Zohoori N, Savitz DA. Econometric approaches to epidemiologic data: Relating endogeneity and unobserved heterogeneity to confounding. Ann Epidemiol 1997; 7(4): 251-257 https://doi.org/10.1016/S1047-2797(97)00023-9
  10. Luft HS, Hunt SS, Maerki SC. The volume-outcome relationship: Practice-makes-perfect or selective-referral patterns? Health Serv Res 1987; 22(2): 157-182
  11. Lee JY, Rozier RG, Norton EC, Vann WF Jr. Addressing selection bias in dental health services research. J Dent Res 2005; 84(10): 942-946 https://doi.org/10.1177/154405910508401013
  12. Rosenbaum PR, Rubin DB. The central role of the propensity score in observational studies for causal effects. Biometrika 1983; 70(1): 41-55 https://doi.org/10.1093/biomet/70.1.41
  13. D'Agostino RB Jr. Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. Stat Med 1998; 17(19): 2265-2281 https://doi.org/10.1002/(SICI)1097-0258(19981015)17:19<2265::AID-SIM918>3.0.CO;2-B
  14. Rubin DB. Estimating causal effects from large data sets using propensity scores. Ann Intern Med 1997; 127(8 Pt 2): 757-763 https://doi.org/10.7326/0003-4819-127-8_Part_2-199710151-00064
  15. Newhouse JP, McClellan M. Econometrics in outcomes research: The use of instrumental variables. Annu Rev Pub Health 1998; 19(1): 17-34 https://doi.org/10.1146/annurev.publhealth.19.1.17
  16. McClellan MB, Newhouse JP. Overview of the special supplement issue. Health Serv Res 2000; 35(5 Pt 2): 1061-1069
  17. Mennemeyer ST. Can econometrics rescue epidemiology? Ann Epidemiol 1997; 7(4): 249-250 https://doi.org/10.1016/S1047-2797(97)00021-5
  18. Zohoori N, Savitz DA. Econometric approaches to epidemiologic data: Relating endogeneity and unobserved heterogeneity to confounding. Ann Epidemiol 1997; 7(4): 251-257 https://doi.org/10.1016/S1047-2797(97)00023-9
  19. Greenland S. An introduction to instrumental variables for epidemiologists. Int J Epidemiol 2000; 29(4): 722-729 https://doi.org/10.1093/ije/29.4.722
  20. Martens EP, Pestman WR, de Boer A, Belitser SV, Klungel OH. Instrumental variables: Application and limitations. Epidemiology 2006; 17(3): 260-267 https://doi.org/10.1097/01.ede.0000215160.88317.cb
  21. Glymour MM. Natural Experiments and Instrumental Variable Analyses in Social Epidemiology. In: Oakes JM, Kaufman JS, editors. Methods for Social Epidemiology. San Francisco: Jossey-Bass; 2006. p. 429-460
  22. Zeliadt SB, Potosky AL, Penson DF, Etzioni R. Survival benefit associated with adjuvant androgen deprivation therapy combined with radiotherapy for high- and low-risk patients with nonmetastatic prostate cancer. Int J Radiat Oncol Biol Phys 2006; 66(2): 395-402 https://doi.org/10.1016/j.ijrobp.2006.04.048
  23. Brooks JM, Chrischilles EA, Scott SD, Chen-Hardee SS. Was breast conserving surgery underutilized for early stage breast cancer? Instrumental variables evidence for stage II patients from Iowa. Health Serv Res 2003; 38(6): 1385-1402 https://doi.org/10.1111/j.1475-6773.2003.00184.x
  24. Earle CC, Tsai JS, Gelber RD, Weinstein MC, Neumann PJ, Weeks JC. Effectiveness of chemotherapy for advanced lung cancer in the elderly: Instrumental variable and propensity analysis. J Clin Oncol 2001; 19(4): 1064-1070 https://doi.org/10.1200/JCO.2001.19.4.1064
  25. Hadley J, Polsky D, Mandelblatt JS, Mitchell JM, Weeks JC, Wang Q, Hwang YT. An exploratory instrumental variable analysis of the outcomes of localized breast cancer treatments in a Medicare population. Health Econ 2003; 12(3): 171-186 https://doi.org/10.1002/hec.710
  26. Bao Y, Duan N, Fox SA. Is some provider advice on smoking cessation better than no advice? An instrumental variable analysis of the 2001 National Health Interview Survey. Health Serv Res 2006; 41(6): 2114-2135 https://doi.org/10.1111/j.1475-6773.2006.00592.x
  27. Schwartz M, Ash AS. Estimating the effect of an intervention from observational data. In: lezzoni LI, editor. Risk Adjustment For Measuring Health Care Outcomes. 3rd ed. Aun Arbor: AcademyHealth/Health Administration Press; 2003
  28. Landrum MB, Ayanian JZ. Causal effect of ambulatory specialty care on mortality following myocardial infarction: A comparison of propensity score and instrumental variable analyses. Health Serv Outcome Res Meth 2001; 2(3-4) : 221-245 https://doi.org/10.1023/A:1020367111374
  29. Posner MA, Ash AS, Freund KM, Moskowitz MA, Shwartz M. Comparing standard regression, propensity score matching, and instrumental variables methods for determining the influence of mammography on stage of diagnosis. Health Serv Outcome Res Meth 2001; 2(3-4): 279-290 https://doi.org/10.1023/A:1020323429121
  30. Stukel TA, Fisher ES, Wennberg DE, Alter DA, Gottlieb DJ, Vermeulen MJ. Analysis of observational studies in the presence of treatment selection bias: Effects of invasive cardiac management on AMI survival using propensity score and instrumental variable methods. JAMA 2007; 297(3): 278-285 https://doi.org/10.1001/jama.297.3.278
  31. Yoon T, Hwang I, Sohn H, Koh K, Jeong B. The determinants of private health insurance purchasing decisions under national health insurance system in Korea. Kor J Health Pol Admin 2005; 15(4): 161-175 (Korean) https://doi.org/10.4332/KJHPA.2005.15.4.161
  32. Kang SW, Kwon YD, You CH. Effects of supplemental insurance on health care utilization and expenditures among cancer patients in Korea. Kor J Health Pol Admin 2005; 15(4): 65-80 (Korean) https://doi.org/10.4332/KJHPA.2005.15.4.065
  33. Lim JH, Kim SG, Lee EM, Bae SY, Park JH, Choi KS, Hahm MI, Park EC. The determinants of purchasing private health insurance in Korean cancer patients. J Prev Med Public Health 2007; 40(2) : 150-154 (Korean) https://doi.org/10.3961/jpmph.2007.40.2.150
  34. Korea Labor Institute. Korean Labor and Income Panel Study (KLIPS) User's Guide. Korea Labor Institute; 2006 (Korean)
  35. Rubin DB. Estimating causal effects from large data sets using propensity scores. Ann Intern Med 1997; 127(8 Pt 2): 757-763 https://doi.org/10.7326/0003-4819-127-8_Part_2-199710151-00064
  36. Parsons LS. Performing a 1:N case-control match on propensity score. Proceedings of the Twenty-Ninth Aunual SAS${\circledR}$ Users Group International Conference. Montreal: SAS Institute Inc.; 2004
  37. Greene WH. Econometric Analysis. 5th ed. Upper Saddle River: Prentice Hall; 2003
  38. Smith JA, Todd PE. Does matching overcome LaLonde's critique of nonexperimental estimators? J Econom 2005; 125(1-2) : 305-353 https://doi.org/10.1016/j.jeconom.2004.04.011
  39. Shah BR, Laupacis A, Hux JE, Austin PC. Propensity score methods gave similar results to traditional regression modeling in observational studies: A systematic review. J Clin Epidemiol 2005; 58(6): 550-559 https://doi.org/10.1016/j.jclinepi.2004.10.016
  40. Angrist JD, Krueger AB. Instrumental variables and the search for identification: From supply and demand to natural experiment. J Econ Persp 2001; 15(1): 69-85