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The Effect of 12 Weeks Combind Exercise on C-reactive protein, Adiponectin and Insulin Resistance in Obese Middle School Girls

복합운동이 비만 여중생의 인슐린저항성 지표와 C-반응단백, 아디포넥틴에 미치는 효과

  • Jeon, Jae-Young (Department of Physical Education, Pusan National University) ;
  • Kwak, Yi-Sub (Department of Leisure and sport Science, Dong-Eui University)
  • 전재영 (부산대학교 체육교육과) ;
  • 곽이섭 (동의대학교 레저스포츠학과)
  • Published : 2007.10.30

Abstract

The purpose of the present investigation was to determine the effect of combine exercise on C-reactive protein(CRP) and adiponectin, and to asses whether combine exercise-induced changes in insulin resistance could be explained in part by changes in these in these inflammation markers. Twenty two participants (BMI >95 percentile for age and sex) were allocated exercise group(n=12) and control group(n=10). Subjects had their body shape, body composition, glucose. insulin, HOMA-IR, CPR and adiponectin levels measured. Modest improvements in body composition, insulin resistance markers were observed, however, adiponectin and CRP did not changes. These data suggest that adiponectin and CRP is not a contributory factor to the exercise-relateted improvements in insulin resistance. Additional studies are needed to assess the effects of different duration, modes and intensities of exercise on inflammation markers.

비만 여자 중학생을 대상으로 12주간 12주간 유산소운동과 저항운동을 병행한 복합운동 프로그램을 실시한 결과는 다음과 같다. 본 연구에서 체중감소와 체지방의 감소에 따른 CRP와 아디포넥틴 농도의 개선을 기대하였지만 유의한 변화가 없었다. 본 연구에서는 다음과 같은 결론을 내린다. 1. 12주간의 중강도 운동 프로그램은 혈장 CRP와 혈장 아디포넥틴의 유용한 개선에 영향을 미치지 않는다. 2. 운동에 의한 인슐린저항성은 이러한 특별한 혈장 염증 지표들의 농도 변화에 의해 설명되어지지 않는다. 이상으로 본 연구에서 처방된 운동프로그램은 신체조성과 인슐린저항성의 변화에는 긍정적인 영향을 미쳤지만 이러한 인자의 개선에도 불구하고 CRP와 아디포넥틴 농도의 변화에는 영향을 미치지 못하였다. 따라서 앞으로 16주 이상의 운동기간과 운동강도에 따른 복합운동 프로그램의 실시가 CRP와 아디포넥틴의 변화에 미치는 영향과 CRP의 발현에 관련인자인 $TNF-{\alpha}$, IL-6 등과 같은 인자들의 변화에 미치는 추가적인 연구가 필요하다.

Keywords

References

  1. American College of Sports Medicine. 2000. ACSM's Guidelines for Exercise Testing and Prescription. 6th Ed. Philadelphia: Lippincott, Williams & Wilkins.
  2. Arita, Y., S. Kihara, N. Ouchi, M. Takahashi, K. Maeda and J. Miyagawa. 1999. Paradoxical decrease of an adipose- specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257(1), 79-83. https://doi.org/10.1006/bbrc.1999.0255
  3. Arner, P. 2003. The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones. Trends Endocrinol. Metab. 14(3), 137-145. https://doi.org/10.1016/S1043-2760(03)00024-9
  4. Baumann, H. and J. Gauldie. 1994. The acute phase response. Immunol. Today 15(2), 74-80. https://doi.org/10.1016/0167-5699(94)90137-6
  5. Blair, S. N. and S. Brodney. 1999. Effects of physical inactivity and obesity on morbidity and mortality: current evidence and research issues. Med. Sci. Sports Exerc. 31, 646-662. https://doi.org/10.1097/00005768-199905000-00004
  6. Boule, N. G., S. J. Weisnagel, T. A. Lakka, A. Tremblay, R. N. Bergman and T. Rankinen. 2005. Effects of exercise training on glucose homeostasis: the HERITAGE Family Study. Diabetes Care 28(1), 108-114. https://doi.org/10.2337/diacare.28.1.108
  7. Bruun, J. M., A. S. Lihn, C. Verdich, S. B. Pedersen, S. Toubro, A. Astrup and B. Richelsen. 2003. Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am. J. Physiol. Endocrinol. Metab. 285(3), E527-533.
  8. Dao, H. H., M. L. Frelut, G. Peres, P. Bourgeois and J. Navarro. 2004. Effects of a multidisciplinary weight loss intervention on anaerobic and aerobic aptitudes in severely obese adolescents. Int. J. Obes. Relat. Metab. Disord. 28(7), 870-878. https://doi.org/10.1038/sj.ijo.0802535
  9. Dietz, W. H. and S. L. Gortmaker. 1984. Factors within the physical environment associated with childhood obesity. Am. J. Clin. Nutr. 139(4), 619-624.
  10. Febbraio, M. A. and B. K. Pedersen. 2002. Muscle- derived interleukin-6: mechanisms for activation and possible biological roles. FASEB. J. 16(11), 1335-1347. https://doi.org/10.1096/fj.01-0876rev
  11. Feingold, K. R. and C. Grunfeld. 1992. Role of cytokines in inducing hyperlipidemia. Diabetes 41(2), 97-101. https://doi.org/10.2337/diab.41.2.S97
  12. Goran, M. I., T. R. Nagy, B. A. Gower, M. Mazariegos, N. Solomons, V. Hoodm and R. Johnson. 1998. Influence of sex, seasonality, ethnicity, and geographic location on the components of total energy expenditure in young children: implications for energy requirements. Am. J. Clin. Nutr. 68(3), 675-682. https://doi.org/10.1093/ajcn/68.3.675
  13. Hevener, A. L., D. Reichart and J. Olefsky. 2000. Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat. Diabetes 49(12), 2154-2159. https://doi.org/10.2337/diabetes.49.12.2154
  14. Horowitz, J. F. 2003. Fatty acid mobilization from adipose tissue during exercise. Trends Endocrinol. Metab. 14(8), 386-392. https://doi.org/10.1016/S1043-2760(03)00143-7
  15. Hotamisligil, G. S., D. L. Murray, L. N. Choy and B. M. Spiegelman. 1994. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc. Natl. Acad. Sci. 91(11), 4854-4858. https://doi.org/10.1073/pnas.91.11.4854
  16. Hotamisligil, G. S., N. S. Shargill and B. M. Spiegelman. 1993. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259(5091), 87-91. https://doi.org/10.1126/science.7678183
  17. Hotta, K., T. Funahashi, Y. Arita, M. Takahashi, M. Matsuda and Y. Okamoto. 2000. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb. Vasc. Biol. 20(6), 1595-1599. https://doi.org/10.1161/01.ATV.20.6.1595
  18. Hu, E., P. Liang and B. M. Spiegelman. 1996. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 271(18), 10697-10703. https://doi.org/10.1074/jbc.271.18.10697
  19. Hulver, M. W., D. Zheng, C. J. Tanner, J. A. Houmard, W. E. Kraus and C. A. Slentz. 2002. Adiponectin is not altered with exercise training despite enhanced insulin action. Am. J. Physiol. Endocrinol. Metab. 283(4), 861-865. https://doi.org/10.1152/ajpendo.00150.2002
  20. Ivy, J. L. 1997. Role of exercise training in the prevention and treatment of insulin resistance and non-insulindependent diabetes mellitus. Sports Med. 24(5), 321-336. https://doi.org/10.2165/00007256-199724050-00004
  21. Kelly, A. S., J. Steinberger, T. P. Olson and D. R. Dengel. 2007. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism 56(7), 1005-1009. https://doi.org/10.1016/j.metabol.2007.03.009
  22. King, D. E., P. Carek, A. G. Mainous and W. S. Pearson. 2003. Inflammatory markers and exercise: differences related to exercise type. Med. Sci. Sports Exerc. 35(4), 575-581. https://doi.org/10.1249/01.MSS.0000058440.28108.CC
  23. Kokkinos, P. F., P. Narayan and V. Papademetriou. 2001. Exercise as hypertension therapy. Cardiol. Clin. 19(3), 507-516. https://doi.org/10.1016/S0733-8651(05)70232-0
  24. Kondo, T., I. Kobayashi and M. Murakami. 2006. Effect of exercise on circulating adipokine levels in obese young women. Endocr. J. 53(2), 189-195. https://doi.org/10.1507/endocrj.53.189
  25. Kondo, H., I. Shimomura, Y. Matsukawa, M. Kumada, M. Takahashi and M. Matsuda. 2002. Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes 51(7), 2325-2328. https://doi.org/10.2337/diabetes.51.7.2325
  26. LeMura, L. M. and M. T. Maziekas. 2002. Factors that alter body fat, body mass, and fat-free mass in pediatric obesity. Med. Sci. Sports Exerc. 34(3), 487- 496. https://doi.org/10.1097/00005768-200203000-00016
  27. Marcell, T. J., K. A. McAuley, T. Traustadottir, and P. D. Reaven. 2005. Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism 54(4), 533-541. https://doi.org/10.1016/j.metabol.2004.11.008
  28. Matthews, D. R., J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher and R. C. Turner. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7), 412-419. https://doi.org/10.1007/BF00280883
  29. McLaughlin, T., F. Abbasi, C. Lamendola, L. Liang, G. Reaven and P. Schaaf. 2002. Differentiation between obesity and insulin resistance in the association with C-reactive protein. Circulation 106(23), 2908-2912. https://doi.org/10.1161/01.CIR.0000041046.32962.86
  30. McMurray, R. G., J. S. Harrel, A. A. Levine and S. A. Gansky. 1995. Childhood obesity elevates blood pressure and total cholesterol independent of physical activity. Int. J. Obes. Relat. Metab. Disord. 19(12), 881-886.
  31. Mohamed-Ali, V., S. Goodrick, A. Rawesh, D. R. Katz, J. M. Miles and J. S. Yudkin. 1997. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J. Clin. Endocrinol. Metab. 82(12), 4196-4200. https://doi.org/10.1210/jc.82.12.4196
  32. Nassis, G. P., K. Papantakou, K. Skenderi, M. Triandafillopoulou, S. A. Kavouras, M. Yannakoulia. 2005. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism 54(11), 1472-1479. https://doi.org/10.1016/j.metabol.2005.05.013
  33. Nicklas, B. J., W. Ambrosius, S. P. Messier, G. D. Miller, B. W. Penninx and R. F. Loeser. 2004. Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. Am. J. Clin. Nutr. 79(4), 544- 551. https://doi.org/10.1093/ajcn/79.4.544
  34. Olson, T. P., D. R. Dengel, A. S. Leon and K. H. Schmitz. 2007. Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women. Int. J. Obes (Lond). 31(6), 996- 1003. https://doi.org/10.1038/sj.ijo.0803534
  35. Ostrowski, K., P. Schjerling and B. K. Pedersen. 2000. Physical activity and plasma interleukin-6 in humans-- effect of intensity of exercise. Eur. J. Appl. Physiol. 83(6), 512-515. https://doi.org/10.1007/s004210000312
  36. Ouchi, N., S. Kihara, T. Funahashi, T. Nakamura, M. Nishida and M. Kumada. 2003. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation 107(5), 671-674. https://doi.org/10.1161/01.CIR.0000055188.83694.B3
  37. Ouchi, N., S. Kihara, Y. Arita, K. Maeda, H. Kuriyama and Y. Okamoto. 1999. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100(25), 2473-2476. https://doi.org/10.1161/01.CIR.100.25.2473
  38. Reseland, J. E., S. A. Anderssen, K. Solvoll, I. Hjermann, P. Urdal and I. Holme. 2001. Effect of long-term changes in diet and exercise on plasma leptin concentrations. Am. J. Clin. Nutr. 73(2), 240-245. https://doi.org/10.1093/ajcn/73.2.240
  39. Ridker, P. M., J. E. Buring, J. Shih, M. Matias and C. H. Hennekens. 1998. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation 98(8), 731-733. https://doi.org/10.1161/01.CIR.98.8.731
  40. Ryan, A. S., B. J. Nicklas, D. M. Berman and D. Elahi. 2003. Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women. Int. J. Obes. Relat. Metab. Disord. 27(9), 1066-1071. https://doi.org/10.1038/sj.ijo.0802387
  41. Shephard, R. J. 2002. Cytokine responses to physical activity, with particular reference to IL-6: sources, actions, and clinical implications. Crit. Rev. Immunol. 22(3), 165-182.
  42. Suzuki, M. 1996. Dumbbell exercise and health. The 1st international symposium on dumbbell exercise 1-5.
  43. Tanner, C. J., T. R. Koves, R. L. Cortright, W. J. Pories, Y. B. Kim and B. B. Kahn. 2002. Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle- aged men. Am. J. Physiol. Endocrinol. Metab. 282(1), E147-153.
  44. Tchernof, A., A. Nolan, C. K. Sites and P. A. Ades. 2002. Poehlman ET. Weight loss reduces C-reactive protein levels in obese postmenopausal women. Circulation 105(5), 564-569. https://doi.org/10.1161/hc0502.103331
  45. Toft, A. D., L. B. Jensen, H. Bruunsgaard, T. felt, J. Halkjaer-Kristensen and M. Febbraio. 2002. Cytokine response to eccentric exercise in young and elderly humans. Am. J. Physiol. Cell Physiol. 283(1), C289-95. https://doi.org/10.1152/ajpcell.00583.2001
  46. Watts, K., P. Beye, A. Siafarikas, G. O'Driscoll and T. W. Jones. 2004. Effects of exercise training on vascular function in obese children. J. Pediatr. 144(5), 620-625. https://doi.org/10.1016/j.jpeds.2004.02.027
  47. Weyer, C., T. Funahashi, S. Tanaka, K. Hotta, Y. Matsuzawa and R. E. Pratley. 2001. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J. Clin. Endocrinol Metab. 86(5), 1930-1935. https://doi.org/10.1210/jc.86.5.1930
  48. Yamauchi, T., K. Hara, N. Kubota, Y. Terauchi, K. Tobe and P. Froguel. 2003a. Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine. Curr. Drug. Targets Immune Endocr. Metabol. Disord. 3(4), 243-254. https://doi.org/10.2174/1568008033340090
  49. Yamauchi, T., J. Kamon, H. Waki, Y. Imai, N. Shimozawa and K. Hioki. 2003b. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J. Biol. Chem. 278(4), 2461-2468. https://doi.org/10.1074/jbc.M209033200
  50. Yamauchi, T., J. Kamon, H. Waki, Y. Terauchi, N. Kubota and K. Hara. 2001. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7(8), 941-946. https://doi.org/10.1038/90984
  51. Yang, W. S., W. J. Lee, T. Funahashi, S. Tanaka, Y. Matsuzawa and C. L. Chao. 2001. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J. Clin. Endocrinol. Metab. 86(8), 3815-3819. https://doi.org/10.1210/jc.86.8.3815
  52. Youngren, J. F., S. Keen, J. L. Kulp, C. J. Tanner, J. A. Houmard and I. D. Goldfine. 2001. Enhanced muscle insulin receptor autophosphorylation with short-term aerobic exercise training. Am. J. Physiol. Endocrinol. Metab. 280(3), E528-533.
  53. You, T., D. M. Berman, A. S. Ryan and B. J. Nicklas. 2004. Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women. J. Clin. Endocrinol. Metab. 89(4), 1739- 1746. https://doi.org/10.1210/jc.2003-031310