한국임상약학회지 (Korean Journal of Clinical Pharmacy)
- 제17권1호
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- Pages.33-37
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- 2007
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
흰쥐에서 아톨바스타틴과 딜티아젬의 약물동태학적 상호작용
Pharmacokinetic Interaction Between Diltiazem and Atorvastatin in Rats
- Chung, Joong-Hwa (College of Medicine, Chosun University) ;
- Kim, Hyun-Yong (College of Pharmacy, Chosun University) ;
- Choi, Jun-Shik (College of Pharmacy, Chosun University)
- 발행 : 2007.06.30
초록
The purpose of this study was to investigate the effect of atorvastatin on the pharmacokinetics of diltiazem (15 mg/kg) after oral administration of diltiazem with or without atorvastatin (0.5, 1.5 and 3.0 mg/kg) in rats. Coadministration of atorvastatin increased significantly (p<0.05, 3.0 mg/kg) the plasma concentration-time curve (AUC) and the peak concentration