References
- Bishop JM: Viral oncogenes. Cell 1985;42:23
- Hayward JR, Regezi JA: Oral dysplasia and in situ carcinoma: Clinicopathologic correlation of eight patients. J Oral Surg 1977; 35:756-762
- Donehower LA, Harvey M, Slangle BL, McArthur M, Montgomery CA, Butel JS, et al: Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 1992;356:215-21 https://doi.org/10.1038/356215a0
- Levine AJ, Momand J, Finlay CA: The p53 tumor suppressor gene. Nature 1991;351:453-456 https://doi.org/10.1038/351453a0
- Irwin MS, Kaelin WG Jr: Role of the newer p53 family proteins in malignancy. Apoptosis 2001;6:17-29 https://doi.org/10.1023/A:1009663809458
- Nylander K, Dabelsteen E, Hall PA: The p53 molecule and its prognostic role in squamous cell carcinomas of the head and neck. J Oral Pathol Med 2000;29:413-25 https://doi.org/10.1034/j.1600-0714.2000.290901.x
- Prives C, Hall PA: The p53 pathway. J Pathol 1999;187:112-26 https://doi.org/10.1002/(SICI)1096-9896(199901)187:1<112::AID-PATH250>3.0.CO;2-3
- Hollstein M, Sidransky D, Vogelstein B, Harris CC: p53 mutations in human cancers. Science 1991;253:49-53 https://doi.org/10.1126/science.1905840
- Ahomadegbe C, Barrois M, Fogel S, Le Bihan ML, Douc-Rasy S, Duvillard P, et al: High incidence of p53 alterations (mutation, deletion, overexpression) on head and neck primary tumors and metastases; absence of correlation with clinical outcome. Frequent protein overexpression in normal epithelium and in early noninvasive lesions. Oncogene 1995;10:4855-78
- Greenblatt MS, Bennett WP, Hollstein M, Harris CC: Mutations in p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenes-is. Cancer Res 1994;54:485-578
- Ness M, Homann N, Discher H, Andl T, et al: Expression of mutated p53 occurs in tumor distant epithelia of head and neck cancers patients: A possible molecular basis for development of multiple tumors. Cancer Res 1993;53:4189-96
- Yang A, Kagdah M, Wang Y, et al: p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 1998;2:305-316 https://doi.org/10.1016/S1097-2765(00)80275-0
- Kaelin WG: The p53 gene family. Oncogene 1999;18:7701-7705 https://doi.org/10.1038/sj.onc.1202955
- Trink B, Okami K, Wu L, et al: A new human p53 homologue. Nat Med 1998;4:747-748 https://doi.org/10.1038/nm0798-747
- Osada M, Ohba M, Kawahara C, et al: Cloning and functional analysis of human p51, which structurally and functionally resembles p35. Nat Med 1998;4:839-843 https://doi.org/10.1038/nm0798-839
- Senoo M, Seki N, Ohira M, et al: A second p53-related protein, p73L, with high homology to p73. Biochem Biophys Res Commun 1998; 30:603-607
- Marin MC, Kaelin WG Jr: p63 and p73: Old members of a new family. Biochem Biophys Acta 2000;1470:M93-M100
- A. Yang, M. Kaghad, Y. Wang, E. Gillett, M.D. Fleming, V: D¨otsch, N.C. et al. p63, a p53 homolog at 3q27-29 encodes multiple products with transactivating, death-inducing, and dominant negative activities. Mol Cell 1998;2:305-316 https://doi.org/10.1016/S1097-2765(00)80275-0
- K.M. Liefer, M.I. Koster, X.J. Wang, A. Yang, F. McKeon, D.R. Roop. Down-regulation of p63 is required for epidermal UV-Binduced apoptosis, Cancer Res 2000;60:4016-4020
- A. Yang, F. McKeon. P63 and p73: p53 mimics, menaces and more. Nat Rev Mol Cell Biol 2000;1:199-207 https://doi.org/10.1038/35043127
- K. Hibi, B. Trink, M. Patturajan, W.H. Westra, O.L. Caballero, D.E. et al. AIS is an oncogene amplified in squamous cell carcinoma. Proc Natl Acad Sci USA 2000;97:5462-5467
- A. Yang, R. Schweitzer, D. Sun, M. Kaghad, N. Walker, R.T. Bronson, C. Tabin, et al: p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 1999; 398:714-718 https://doi.org/10.1038/19539
- Tsujita-Kyutoku M, Kiuchi K, Danbara N, Yuri T, Senzaki H, et al. p63 expression in normal human epidermis and epidermal appendages and their tumors. J Cut Pathol 2003;30:11-7 https://doi.org/10.1034/j.1600-0560.2003.300102.x
- Mills AA, Zheng B, Wang X-J, Vogel H, Roop DR, Bradley A: p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 1999;398:708-13 https://doi.org/10.1038/19531
- Donehower LA, Bradley A: The tumor suppressor p53. Biochim Biophys Acta 1993;1155:181-205
- Choi HR, Batsakis JG, Zhan F, Sturgis E, Luna MA, El-Naggar AK: Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis. Hum Pathol 2002; 33:158- 164 https://doi.org/10.1053/hupa.2002.30722
- Crook T, Nicholls JM, Brooks L, O''Nions J, Allday MJ: High level expression of MNp63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC). Oncogene 2000; 19:439-3444
- Davison TS, Vagner C, Kaghad M, Ayed A, Caput D, Arrowsmith CH: p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. J Biol Chem 1999; 274:18709-18714 https://doi.org/10.1074/jbc.274.26.18709
- Strano S, Rossi M, Fontemaggi G, Munarriz E, Soddu S, Sacchi A, Blandino G: From p63 to p53 across p73. FEBS Lett 2001;490:163-170 https://doi.org/10.1016/S0014-5793(01)02119-6
- Augustin M, Bamberger C, Paul D, Schmae H: Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homolog Ket to mouse chromosome 16. Mamm Genome 1998;9:899-902 https://doi.org/10.1007/s003359900891
- Osada M, Ohba M, Kawahara C, Ishioka C, Kanamaru R, et al: Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat Med 1998;4:839-843 https://doi.org/10.1038/nm0798-839
- Davison TS, Vagner C, Kaghad M, Ayed A, Caput D, Arrowsmith CH: p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. J Biol Chem 1999;274:18709-18714 https://doi.org/10.1074/jbc.274.26.18709
- Faridoni-Laurens L, Bosq J, Janot F, Vayssade M, et al: p73 expression in basal layers of head and neck squamous cell epithelium: a role in differentiation and carcinogenesis in concert with p53 and p63? Oncogene 2001;20:5302-5312 https://doi.org/10.1038/sj.onc.1204687
-
Nylander K, Coates PJ, Hall PA: Characterization of the expression pattern of p63
$\alpha$ and$\delta$ Np63a in benign and malignant oral epithelial lesions. Int J Cancer 2000;87:368-372 https://doi.org/10.1002/1097-0215(20000801)87:3<368::AID-IJC9>3.0.CO;2-J - Weber A, Bellmann U, Bootz F, Wittekind C, Tannapfel A: Expression of p53 and its homologues in primary and recurrent squamous cell carcinomas of the head and neck. Int J Cancer 2002;99:22-28 https://doi.org/10.1002/ijc.10296
- Nylander K, Vojtesek B, Nenutil R, Lindgren B, Roos G, et al: Differential expression of p63 isoforms in normal tissues and neoplastic cells. J Pathol 2002;198:417-427 https://doi.org/10.1002/path.1231
- Parsa R, Yang A, McKeon F, Green H: Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol 1999;113:1099-1105 https://doi.org/10.1046/j.1523-1747.1999.00780.x
- Pellegrini G, Dellambra E, Golisano O, et al: p63 identifies keratinocyte stem cells. Proc Natl Acad Sci U S A 2001;13:3156-3161
- OConnell JT, Mutter GL, Cviko A, et al: Identification of a basal/reserve cell immunophenotype in benign and neoplastic endometrium: a study with the p53 homologue p63. Gynecol Oncol 2001;80:30-36 https://doi.org/10.1006/gyno.2000.6026
- Quade BJ, Yang A, Wang Y, et al: Expression of the p53 homologue p63 in early cervical neoplasia. Gynecol Oncol 2001;80:24-29 https://doi.org/10.1006/gyno.2000.5953
- Signoretti S, Waltgreny D, Dilks J, et al: p63 is a prostate basal cell marker and is required for prostate development. Am J Pathol 2000;157:1769-1775 https://doi.org/10.1016/S0002-9440(10)64814-6
-
Senoo M, Tsuchiya I, Matsumura Y, et al: Transcriptional dysregulation of the p73L/p63/p51/p40/KET gene in human squamous cell carcinomas: expression of
$\delta$ Np73L, a novel dominantnegative isoform, and loss of expression of the potential tumour suppressor p51. Br J Cancer 2001;84:1235-1241 https://doi.org/10.1054/bjoc.2000.1735 - Barbareschi M, Pecciarini L, Cangi MG, et al: p63, a p53 homologue, is a selective marker of myoepithelial cells of the human breast. Am J Surg Pathol 2001;25:1054-1060 https://doi.org/10.1097/00000478-200108000-00010
-
Hall PA, Campbell SJ, O''Neill M, et al: The expression of the p53 homologue, p63
$\alpha$ and Np63$\alpha$ in normal and neoplastic cells. Carcinogenesis 2000;21:153-160 https://doi.org/10.1093/carcin/21.2.153 - Tannapfel A, Schmelzer S, Benicke M, et al: Expression of the p53 homologues p63 and p73 in multiple simultaneous gastric cancer. J Pathol 2001;195:163-170 https://doi.org/10.1002/path.947
- Di Como CJ, Urist MJ, Babayan I, et al: p63 expression profiles in human normal and tumor tissues. Clin Cancer Res 2002;8:494-501
-
Hall PA, Woodman AC, Campbell SJ, Shepherd NA: Expression of the p53 homologue p63
$\alpha$ and Np63$\alpha$ in the neoplastic sequence of Barrett'oesophagus: correlation with morphology and p53 protein. Gut 2001;49:618-23 https://doi.org/10.1136/gut.49.5.618 - Faridoni-Laurens L, Bosq J, Janot F, et al: P73 expression in basal layers of head and neck squamous epithelium: a role in differentiation and carcinogenesis in concert with p53 and p63? Oncogene 2001;20: 5302-5312 https://doi.org/10.1038/sj.onc.1204687