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Stereoselective Synthesis of a Novel Cyclohexene Version of Carbovir

  • Li, Hua (BK-21 Team, College of Pharmacy, Chosun University) ;
  • Hong, Joon-Hee (BK-21 Team, College of Pharmacy, Chosun University)
  • Published : 2007.10.20

Abstract

This paper describes a racemic and stereoselective synthetic route for a novel cyclohexenyl carbocyclic adenine analogue. The required stereochemistry of the target compound was controlled using a stereoselective glycolate Claisen rearrangement followed by α-chelated carbonyl addition. The introduction of 6-chloropurine was achieved using Mitsunobu conditions, and further modifications of the corresponding heterocycle gave the target cyclohexenyl nucleoside.

Keywords

References

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