Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis and Characterization of Degradable Polycationic Polymers as Gene Delivery Carriers

  • Kim, Hyun-Jin (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Kwon, Min-Sung (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Choi, Joon-Sig (Department of Biochemistry, Chungnam Natiional University) ;
  • Kim, Bo-Hye (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Yoon, Jae-Keun (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Kim, Kwan (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Park, Jong-Sang (School of Chemistry & Molecular Engineering, Seoul National University)
  • Published : 2007.01.20
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Abstract

Biodegradable cationic poly(ester-amide) polymers were synthesized by double-monomer method, that showed excellent solubility in many organic solvents and water. Different degradation patterns were obtained by the regulation of monomer ratios and overall long period of time of DNA protection up to 12 days was shown by PicoGreen reagent assay. Good transfection profiles in the presence of serum and very low toxicity on mammalian cells may allow these polymers to become suitable for long-term gene delivery systems and therapeutic applications.

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References

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