Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Direct Organocatalytic Regioselective α-Hydroxyamination of α-Branched Aldehydes

  • Kim, Sung-Gon (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Ahn, Eun-Ju (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Park, Tae-Ho (Medicinal Science Division, Korea Research Institute of Chemical Technology)
  • Published : 2007.10.20
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Abstract

A direct regioselective α-hydroxyamination of α-branched aldehydes with nitrosobenzene using cis-5-benzylproline as catalyst has been developed for the preparation of α-hydroxyamino aldehydes possessing a quaternary carbon center. Such compounds are versatile building blocks for the synthesis of quaternary α- amino acids, β-amino alcohols, and 1,2-diamines.

Keywords

References

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