Journal of the Korean Dietetic Association (대한영양사협회학술지)

The Korean Dietetic Association (대한영양사협회)
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Effect of Sorghum bicolor L. Moench(Sorghum, su-su) Water Extracts on Mouse Immune Cell Activation

수수 물 추출물이 마우스 면역세포와 항체 생성능에 미치는 영향

  • Kim, Gyeong-Ok (Major in Food and Nutrition, College of Life Science, Sookmyung Women's University) ;
  • Kim, Hyeon-Suk (Major in Food and Nutrition, College of Life Science, Sookmyung Women's University) ;
  • Ryu, Hye-Suk (Major in Food and Nutrition, College of Life Science, Sookmyung Women's University)
  • 김경옥 (숙명여자대학교 생활과학대학 식품영양학과) ;
  • 김현숙 (숙명여자대학교 생활과학대학 식품영양학과) ;
  • 류혜숙 (숙명여자대학교 생활과학대학 식품영양학과)
  • Published : 2006.02.02
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Abstract

This study was performed to evaluate the effect of Sorghum bicolor L. Moench(Sorghum, su-su) extracts on mouse immune cell activation. As ex vivo experiment, different concentrations(0, 50, 500mg/kg B.W.) of Sorghum bicolor L. Moench water extracts were orally administrated into mouse every other day for four weeks. The proliferation of mouse splenocytes, the number of plaque forming cells(PFC) and the cytokine IL-1β production by activated macrophage were used as indices for immunocompetence. Splenocyte proliferation was enhanced in mouse orally administrated with 50mg/kg B.W./day concentration compared to that of control group. Especially, the highest proliferation of spleoncyte was seen in the mouse orally administrated at the concentration of 50mg/kg B.W./day. The number of plaque forming cells(PFC) to SRBC were significantly enhanced when compared with control group. Also, the mouse of Sorghum bicolor L. Moench water extracts 50mg/kg B.W./day supplementation group with LPS stimulation enhanced level of IL-1$\beta$ cytokine production. This study suggest that supplementation of Sorghum bicolor L. Moench water extracts may enhance the immune function by regulating the splenocytes proliferation, increasing the number of PFC and enhancing the cytokine production by activated macrophage.

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