The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Yangsim-tang on the Changes of Cerebral Hemodynamics in Rats

양심탕이 백서의 뇌혈류역학 변화에 미치는 영향

  • Shin, Sun-Ho (Department of Internal Medicine, College of Oriental Medicine, WonKwang University) ;
  • Jeon, Sang-Yoon (Department of Internal Medicine, College of Oriental Medicine, DongShin University) ;
  • Hong, Seok (Department of Internal Medicine, College of Oriental Medicine, DongShin University) ;
  • Lee, Jung-Sup (Department of Internal Medicine, College of Oriental Medicine, WonKwang University)
  • 신선호 (원광대학교 한의과대학 심계내과학교실) ;
  • 전상윤 (동신대학교 한의과대학 심계내과학교실) ;
  • 홍석 (동신대학교 한의과대학 심계내과학교실) ;
  • 이정섭 (원광대학교 한의과대학 심계내과학교실)
  • Published : 2006.12.31
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Abstract

Objectives : This study was performed to evaluate effects of Yangsim-tang extract (YST) on hemodynamics (regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) ) in normal rats, and effects of cyclooxygenase and guanylate cyclase under YST. Methods : Laser-Doppler flowmetry (LDF) measured changes of rCBF, and a data acquisition system assembled with MacLab and Macintosh measured changes of MABP. Results : YST significantly increased rCBF, but did not change MABP. Pretreatment with indomethacin significantly inhibited rCBF increased by YST, but pretreatment with methylene blue did not significantly inhibit rCBF increased by YST. Conclusions : YST increases rCBF, and the action of this response is mediated by cyclooxygenase.

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