대한본초학회지 (The Korea Journal of Herbology)
- 제21권4호
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- Pages.77-84
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- 2006
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
가감보양환오탕(加減補陽還五湯)의 N2a 뇌신경세포에 대한 보호효과
Neuroprotective effects of modified Bo-Yang-Hwan-Oh-Tang in N2a neuroblastoma cells
- Lim, Kyu (Department of Herbology, College of Oriental Medicine, Dongguk University) ;
- Park, Yong-Ki (Department of Herbology, College of Oriental Medicine, Dongguk University)
- 발행 : 2006.12.30
초록
Objectives : To evaluate the neuroprotective effects of modified Bo-Yang-Hwan-O-Tang (BHT), we investigated the neuronal death protection effects to oxidative damages in N2a neuroblastoma cells. Methods : To study the cytotoxic effect of BHT on N2a neuronal cells, the cell viability was determined by MTT assay. To investigate the neuronal death protection of BHT, N2a neuronal cells were induced oxidative damages by H2O2, and assayed the cell viability and DNA fragmentation. We also investigated DPPH free radical scavenging effects of BHT by tube test. Results : In MTT assay,
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