The Korea Journal of Herbology (대한본초학회지)
- Volume 21 Issue 4
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- Pages.77-84
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- 2006
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
Neuroprotective effects of modified Bo-Yang-Hwan-Oh-Tang in N2a neuroblastoma cells
가감보양환오탕(加減補陽還五湯)의 N2a 뇌신경세포에 대한 보호효과
- Lim, Kyu (Department of Herbology, College of Oriental Medicine, Dongguk University) ;
- Park, Yong-Ki (Department of Herbology, College of Oriental Medicine, Dongguk University)
- Published : 2006.12.30
Abstract
Objectives : To evaluate the neuroprotective effects of modified Bo-Yang-Hwan-O-Tang (BHT), we investigated the neuronal death protection effects to oxidative damages in N2a neuroblastoma cells. Methods : To study the cytotoxic effect of BHT on N2a neuronal cells, the cell viability was determined by MTT assay. To investigate the neuronal death protection of BHT, N2a neuronal cells were induced oxidative damages by H2O2, and assayed the cell viability and DNA fragmentation. We also investigated DPPH free radical scavenging effects of BHT by tube test. Results : In MTT assay,
Keywords
- Bo-Yang-Hwan-O-Tang extract;
- anti-oxidant effect;
- N2a neuroblastoma;
- H2O2-induced cell death;
- neuroprotecitve effect