Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Association among apolipoprotein E gene polymorphism, diabetes mellitus, and ischemic cerebrovascular disease in Koreans

  • Kim, Do-Hwan (Department of Neurology, Wonkwang University School of Medicine) ;
  • Cho, Kwang-Ho (Department of Neurology, Wonkwang University School of Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Moon, Byung-Soon (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Son, Mu-Song (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Jeong, Se-Jin (Basic institute of Natural Science, Wonkwang University) ;
  • Lee, Hye-Jung (Acupuncture and Meridian Science Research Center, Kyung Hee University) ;
  • Hong, Seung-Heon (College of Pharmacy, Wonkwang University) ;
  • Kim, Hyung-Min (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Um, Jae-Young (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, Acupuncture and Meridian Science Research Center, Kyung Hee University)
  • Published : 2006.12.31
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Abstract

The association between apolipoprotein E (apoE) gene polymorphism and ischemic cerebrovascular disease (ICVD) has been controversial. These controversies may be due to inaccurate classification of patients and ethnic differences. The aim of the present study was to assess the relationship between apoE gene polymorphism and the development of ICVD in a population from Korea. We investigated 136 patients with ICVD and 357 controls without ICVD. No differences in the apoE genotypes frequencies ($X^{2}$ = 3.660, df = 5, P = 0.454) and even in the alleles frequencies ($X^{2}$ = 1.946, df = 2, P = 0.378) were observed in the ICVD patients compared with that in controls. The data have been compared with data found in other population groups. However, the risk of ICVD associated with apoE ${\varepsilon}3/{\varepsilon}4$ genotype was increased nearly 3-fold in subjects possessing the history of diabetes mellitus (OR 3.3, 95% CI 1.2-9.4, P = 0.026). We concluded that the apoE polymorphism is not associated with ICVD at least in the Korean population, but the apoE frequencies found in this study differ significantly from those obtained in Japanese.

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References

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