Korean Journal of Oriental Medicine (한국한의학연구원논문집)
- Volume 12 Issue 3 Serial No. 18
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- Pages.59-67
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- 2006
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- 1229-3377(pISSN)
Effects of electroacupuncture on the expression of iNOS in Nuclei of solitary tract and Rostral ventrolateral medulla in spontaneously hypertensive rats
전침자극이 자연 발증 고혈압 흰쥐의 혈압 조절 중추에서 iNOS의 발현에 미치는 영향
- Hwang, Hye-Suk (Korea Institute of Oriental Medicine) ;
- Kim, Yu-Sung (Korea Institute of Oriental Medicine) ;
- Lee, Ji-Eun (Korea Institute of Oriental Medicine) ;
- Han, Kyung-Ju (Korea Institute of Oriental Medicine) ;
- Choi, Sun-Mi (Korea Institute of Oriental Medicine) ;
- Koo, Sung-Tae (Korea Institute of Oriental Medicine)
- Published : 2006.12.30
Abstract
Aims: Acupuncture has been used for the treatment of essential hypertension, but the efficacy and the mechanism of acupuncture in prevention of hypertension are still unclear. We tested the hypothesis that electroacupuncture (EA) applied to Baekhoe (GV20) changes NO/NOS system during development of hypertension in spontaneously hypertensive rats (SHR), and thereby causes the delay of development of hypertension in SHR. Methods: The male SHR rats in the developmental stages of hypertension (7-8 weeks) were randomly divided into three groups (control group, GV20 acupuncture group, and tail acupuncture group). And the age matched Wistar Koyto Rats (WKY) were randomly divided into two groups (nagative control, GV20 acupuncture group). EA treatments (10Hz, 1mA, 0.1ms) were carried out for 25 min/day for five consecutive days. The systolic blood pressure (SBP) was determined in conscious rats by the tail-cuff method using automatic BP mornitoring system. We investigated the activations of inducible NO synthase (iNOS) in nuclei of solitary tract (NTS) and rostral ventrolateral medulla (RVLM) of SHR by the western blotting method. Results: The SBP after the termination of EA stimulation applied to the GV20 was stabilized at
Keywords
- Hypertension;
- Spontaneously hypertensive rat;
- GV20;
- Nuclei of solitary tract;
- Rostral ventrolateral medulla