Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Breast Cancer Chemopreventive Activity of Polysaccharides from Starfish In Vitro

  • Nam Kyung-Soo (Department of Pharmacology, College of Medicine, Dongguk University) ;
  • Kim Cheorl-Ho (National Research Laboratory for Glycobiology and Department of Biological Science, Sungkyunkwan University) ;
  • Shon Yun-Hee (Intractable Disease Research Center, Dongguk University)
  • Published : 2006.09.01
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Abstract

Polysaccharides from the starfish Asterina pectinifera were assessed in vitro for their chemopreventive potential in human breast cancer. The polysaccharides from A. pectinifera inhibited cell proliferation in the estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) human breast carcinoma cell lines. In addition, the polysaccharides were found to be an inhibitor of cytochrome P450 1A1-mediated ethoxyresorufin O-deethylase activity, and caused a dose-dependent inhibition of aromatase activity in microsomes isolated from a human placenta. There was a significant reduction in the ornithine decarboxylase activity to 30.7% of the control in the polysaccharide-treated MCF-7 breast cancer cells. Therefore, the polysaccharides from A. pectinifera merit further investigation with respect to breast cancer chemoprevention.

Keywords

References

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