Biomedical Science Letters (대한의생명과학회지)
- Volume 12 Issue 3
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- Pages.161-170
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- 2006
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
A Novel Anti-cancer Agent, SJ-8029, Inhibits Angiogenesis and Induces Apoptosis
- Yi Eui-Yeun (Department of Molecular Biology, Pusan National University) ;
- Jeong Eun-Joo (Department of Molecular Biology, Pusan National University) ;
- Song Hyun-Seok (Department of Molecular Biology, Pusan National University) ;
- Kang Dong-Wook (Central Research Institute, Samjin Pharm. Co., Ltd.) ;
- Joo Jeong-Ho (Central Research Institute, Samjin Pharm. Co., Ltd.) ;
- Kwon Ho-Seok (Central Research Institute, Samjin Pharm. Co., Ltd.) ;
- Lee Sun-Hwan (Central Research Institute, Samjin Pharm. Co., Ltd.) ;
- Park Si-Kyung (Central Research Institute, Samjin Pharm. Co., Ltd.) ;
- Chung Sun-Gan (Central Research Institute, Samjin Pharm. Co., Ltd.) ;
- Cho Eui-Hwan (Central Research Institute, Samjin Pharm. Co., Ltd.) ;
- Kim Yung-Jin (Department of Molecular Biology, Pusan National University)
- Published : 2006.09.01
Abstract
A new piperazine derivative, 8J-8029, is a synthetic anti-cancer agent which exhibits both microtubule and topoisomerase II inhibiting activities. In this study, we investigated the ability of 8J-8029 for anti-angiogenesis and apoptosis. 8J-8029 decreased the bFGF-induced angiogenesis in the CAM and the mouse Matrigel implants, in vivo. 8J-8029 inhibited the proliferation, migration, invasion, tube fonnation, and expression of MMP-2 in BAECs. In addition, 8J-8029 reduced the cell viability in HepG2 cells, caused the production of fragmented DNA and the morphological changes corresponding to apoptosis. 8J-8029 also elicited the release of cytochrome c and the activation of caspase-3. Taken together, these results suggest 8J-8029 may be a candidate for anti-cancer agent with the ability to inhibit the angiogenesis of endothelial cells and to induce the apoptosis of tumor cells.