Biomedical Science Letters (대한의생명과학회지)
- Volume 12 Issue 3
- /
- Pages.153-160
- /
- 2006
- /
- 1738-3226(pISSN)
- /
- 2288-7415(eISSN)
The Effect of Taxol and Arsenic Trioxide in HT-29 Spheroid Cells
- Lee In-Soo (Department of Biomedical Laboratory Science, College of Health Science, Yonsei University) ;
- Choi Hyun-Il (Department of Biomedical Laboratory Science, College of Health Science, Yonsei University) ;
- Han Hye-Eun (Department of Biomedical Laboratory Science, College of Health Science, Yonsei University) ;
- Lee Hye-Young (Department of Biomedical Laboratory Science, College of Health Science, Yonsei University) ;
- Kim Tae-Ue (Department of Biomedical Laboratory Science, College of Health Science, Yonsei University)
- Published : 2006.09.01
Abstract
Human colon cancer is the second most fatal disease among a variety of cancers to cause cancer death in U.S.A. and its incidence rate is currently increased in Korea. Recently, many studies have been being progressed on the efficacy of diverse combination treatments. But results of these studies in vitro were not similar those in vivo. This study compared the anticancer reactions between each use of arsenic trioxide and taxol against human colon cancer HT-29 cell line and combined use of two drugs. And these results compared with the results of HT-29 spheroid cells having similar characteristics to the solid tumor in vivo. The spheroid of HT-29 cells was formed by using a multicellular spheroid system and the result was observed through electron microscopy. In vitro cytotoxicity of each use of arsenic trioxide and taxol was evaluated in HT-29 monolayer cells. The