Journal of the Korean Electrochemical Society (전기화학회지)

The Korean Electrochemical Society (한국전기화학회)
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The Potentiometric Performances of Membrane Electrodes Based on Tetracycline Antibiotics

테트라싸이크린 항생제를 담체로 이용한 막전극의 전위차 특성

  • Published : 2006.08.01
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Abstract

The main component governing selectivity in ion-selective electrodes and optodes is the ionophore. For this reason, a member of natural products that possess selective ion-binding properties have long been sought after. By applying this principle, the performance of tetracycline used as neutral carriers for cation selective polymeric membrane electrode was investigated. The cation ion-selective electrode based on tetracycline gave a good Nernstian response of 26.6 mV per decade for calcium ion in the activity range $1x10^{-6}M$ to $1x10^{-2}M$ with and without lipophilic additives. The optimized cation ion-selective membrane electrodes displayed very comparable potentiometric responses to various mono and di-valent cations of alkali and alkaline earth metal ions except $Mg^{2+}$.

본 연구에서는 테트라싸이크린 항생제를 양이온선택성 전극의 담체로 사용한 막전극을 제작하고 알칼리 및 알칼리 토금속에 적용하여 전위차 감응도를 조사하였다. 제작된 전극은 지용성 첨가제의 유무와 관계없이 $Ca^{2+}$ 이온에 대해서 거의 이상적인 전위차 감응도를 나타내었다. 또한 $Mg^{2+}$를 제외한 다른 양이온에도 이상적인 네른스트값에 80% 이상의 감응도와 $10^{-5}$ 이하의 검출한계를 나타내었다. 수명, 감응시간, 재현성 등도 이온선택성 전극에 응용하기에 문제가 없었다.

Keywords

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  1. The Potentiometric Performances of the Cation Selective Electrodes based on Tetracycline and Chemically Modified Tetracycline vol.2, pp.3, 2011, https://doi.org/10.5229/JECST.2011.2.3.143
  2. Electrochemical biosensors in pharmaceutical analysis vol.46, pp.3, 2010, https://doi.org/10.1590/S1984-82502010000300002