Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
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Effects of Pomegranate Peel (Granati pericarpium) Extracts on the Antioxidant Biomarkers in C57BL/6J Mice Fed a High Fat and Cholesterol Diet

석류 껍질 추출물이 고지방 고콜레스레롤 식이 급여 C57BL/6J 마우스의 항산화 지표 및 DNA 보호에 미치는 영향

  • Oh Sang-Hee (Dept. of Food and Nutrition, Chungnam National University) ;
  • Yang Yun-Hyoung (Dept. of Food and Nutrition, Chungnam National University) ;
  • Sok Dai-Eun (College of Pharmacy, Chungnam National University) ;
  • Kim Mee-Ree (Dept. of Food and Nutrition, Chungnam National University)
  • Published : 2006.08.01
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Abstract

The present study evaluated the effects of pomegranate peel (Granati pericarpium) extract on the lipid profiles and antioxidant biomarkers in mice fed a high fat and cholesterol diet: the measured biomarkers included the TBARS value, GPx, GR, SOD and GST activities. Body fat depositions were significantly decreased in the group that received pomegranate peel. In addition, the activities of GPx, GST and SOD were significantly higher in the liver and plasma of the pomegranate peel group than in the control group. Also, the pomegranate peel diet decreased lipid peroxidation of the liver and kidney. Alkaline single-cell gel electrophoresis (comet assay) showed that the DNA damage in the plasma of the pomegranate peel group was decreased compared to that of control. The present results show that a diet with added pomegranate peel exerts protective effects against oxidative DNA damage and lipid peroxidation possibly via effects on the free radical levels in mice fed a high fat and cholesterol diet.

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