Early and Midterm Results of Coronary Artery Bypass Grafting in Patients with Ischemic Cardiomyopathy ${(LVEF{\leq}35%)}$

허혈성 심근질환(좌심실박출지수${\leq}$35%) 환자에서 관상동맥우회술의 조기와 중기 결과

  • Cho Sung-Woo (Department of Thoracic and Cardiovascular Surgery, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University) ;
  • Lee Young-Tak (Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Choi Jin-Ho (Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim Si-Wook (Department of Thoracic and Cardiovascular Surgery, Chungbuk Nation University Hospital, Chungbuk Nation University College of Medicine) ;
  • Park Kay-Hyun (Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital) ;
  • Park Pyo-Won (Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Sung Ki-Ick (Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 조성우 (한림대학교 의과대학 강동성심병원 흉부외과) ;
  • 이영탁 (성균관대학교 의과대학 삼성서울병원 흉부외과) ;
  • 최진호 (성균관대학교 의과대학 삼성서울병원 흉부외과) ;
  • 김시욱 (충북대학교 의과대학 부속병원 흉부외과) ;
  • 박계현 (분당서울대학교병원 흉부외과) ;
  • 박표원 (성균관대학교 의과대학 삼성서울병원 흉부외과) ;
  • 성기익 (성균관대학교 의과대학 삼성서울병원 흉부외과)
  • Published : 2006.08.01

Abstract

Background: Recent improvements in interventional procedure and medical therapy for congestive heart failure result in an increase of number of patients with ischemic cardiomyopathy considered for coronary artery bypass grafting. We retrospectively review the results of CABG in these patients with decreased LV function to know the early and mid-term follow-up results. Material and Method: Between January 2001 and June 2005, 1,143 patients underwent coronary artery bypass grafting and 144 of these patients had preoperative left ventricular function of equal to or less than 35% ${(LVEF{\leq}\;35%)}$. There were off-pump coronary artery bypass grafting (OPCAB) in 66 cases (45.8%), on-pump beating heart coronary artery bypass grafting in 34 cases (23.6%) and conventional coronary artery bypass grafting in 44 cases (30.6%). The combined operations including mitral annuloplasty were 48 cases in thirty five patients (24.3%). Result: The mean number of dstal anastomosis were $3.5{\pm}1.3$. The median postoperative duration of stay in intensive care unit and hospital was 2 days and 8 days, respectively. There were 6 early death (4.2%) and causes of deaths were ventricular tachycardia in 5 patients, small bowel infarction in one patient. Mean follow-up time was $21{\pm}14$ months $(4{\sim}54\;months)$. The 1-year was $95{\pm}2%$ and 3-year survival rate was $83{\pm}7%$, the 1-year and 3-year cardiac event-free survival were ${88{\pm}3%\;and\;69{\pm}7%}$, respectively. Conclusion: Based on satisfactory early and mid-term results in our study, CABG should be carried out as actively as possible in patients with ischemic cardiomyopathy. Postoperative aggressive management for ventricular arrhythmia would be helpful for better results.

배경 : 최근 중재적 시술과 심부전에 대한 내과적 치료의 발전으로 관상동맥우회술의 대상이 되는 허혈성 심근질환을 가진 환자들이 늘어나고 있다. 우리는 좌심실 기능이 감소된 이러한 환자들에 시행 된 관상동맥우회술의 결과를 후향적으로 분석하여 중단기 결과를 알아보고자 한다. 대상 및 방법: 2001년 1월부터 2005년 6월까지 관상동맥우회술을 시행 받은 1,143 명의 환자 중 죄심실박출지수가 35% 이하인 환자는 144명이었다. 인공심폐기를 사용하지 않고 관상동맥우회술(‘off-pump’ coronary artery bypass grafting, OPCAB) 을 시행한 경우가 66예(45.8%), 인공심폐기를 사용하고 뛰는 심장에서 관상동맥우회술(on-pump beating heart coronary artery bypass grafting)을 시행한 경우가 34예(23.6%), 전통적인 관상동맥우회술(conventional coronary artery bypass grafting)을 시행한 경우가 44예(30.6%) 였다. 동반된 심장수술로는 승모판륜 성형술을 포함하여 35명(24.3%)의 환자들에서 48건이 시행되었다. 결과: 환자당 원위 문합수는 $3.5{\pm}1.3%$개였고 술 후 중환자실 체류기간과 재원기간의 중간값은 각각 2일과 8일이었다. 조기 사망은 6명(4.2%)으로 심실성 빈맥으로 인한 경우가 5명, 소장경색이 1명이었다. 평균 추적기간은 $21{\pm}14%(2{\sim}54$개월)였다. 1년 생존율은 $95{\pm}2%$, 3년 생존율은 $83{\pm}7%$였고 심장관련 event-free 1년, 3년 생존율은 각각 ${88{\pm}3%,\;69{\pm}7%}$였다. 결론: 만족할 만한 중단기 결과에 따라 허혈성 심근질환에서도 적극적으로 관상동맥우회술이 시행되어야 할 것으로 생각되며 술 후 심실성 빈맥에 대한 치료를 집중적으로 시행한다면 더 좋은 결과를 보이리라 생각된다.

Keywords

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