Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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S-Adenosyl-L-Methionine Analogues to Enhance the Production of Actinorhodin

  • Chong You-Hoon (Department of Molecular Biotechnology, Konkuk University) ;
  • Young Jung-Mo (Bio/Molecular Informatics Center, Konkuk University) ;
  • Kim Jin-Young (Department of BioMedical Science and Technology, Konkuk University) ;
  • Lee Yu-Kyung (Bio/Molecular Informatics Center, Konkuk University) ;
  • Park Kwang-Su (Department of Molecular Biotechnology, Konkuk University) ;
  • Cho Jun-Ho (Department of Molecular Biotechnology, Konkuk University) ;
  • Kwon Hyung-Jin (Institute of Bioscience and Biotechnology and Department of Biological Science, Myongji University) ;
  • Suh Joo-WOn (Institute of Bioscience and Biotechnology and Department of Biological Science, Myongji University) ;
  • Lim Yoong-Ho (Bio/Molecular Informatics Center, Konkuk University)
  • Published : 2006.07.01
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Abstract

It is known that overexpression of S-adenosyl-L-methionine (SAM) synthetase or exogenous addition of SAM enhances the production of actinorhodin, one of pigmented antibiotics found from Streptomyces coelicolor. In order to discover a novel compound as a signal molecule to produce actinorhodin instead of SAM, several compounds were synthesized based on the relationships between structures of the SAM analogues and their actinorhodin productivities. Of these, a few compounds showed better productivities of actinorhodin than SAM.

Keywords

References

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